Restauration of age related motor impairment: role of IGF-1 based gene therapy and microglial activation

In the current study we implemented ICV IGF-1 gene therapy in very old rats (28 months) and assessed the motor performance pre and 17-days after surgery. Glial immunoreactivity in striatum was evaluated by Iba1 and GFAP markers.

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Detalles Bibliográficos
Autores principales:	Falomir Lockhart, Eugenia, Millan, J., Anesetti Nelli, S., Hereñú, Claudia Beatriz, Bellini, María José
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2015
Materias:	Ciencias Médicas Microglía
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/59228 http://revista.med.unlp.edu.ar/archivos/201512/Restaurationof_age_related_motor_impairment.pdf http://revista.med.unlp.edu.ar/archivos/201512/posters/p_Restauration_of_age_related_motor_impairment_role_of_igf-1_based_gene_therapy_and_microglial_activation.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

Descripción
Sumario:	In the current study we implemented ICV IGF-1 gene therapy in very old rats (28 months) and assessed the motor performance pre and 17-days after surgery. Glial immunoreactivity in striatum was evaluated by Iba1 and GFAP markers.