Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

Ipomoea carnea subsp. fistulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these...

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Autores principales:	Ríos, Elvio E., Cholich, Luciana, Gimeno, Eduardo Juan, Guidi, María Guadalupe, Acosta de Pérez, Ofelia C.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Ciencias Veterinarias CNS lesions Capra hircus goats Ipomoea Ipomoea carnea plant poisoning poisonous plants transmission electron microscopy
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/40263 http://www.scielo.br/pdf/pvb/v32n1/v32n1a07.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-40263
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias CNS lesions Capra hircus goats Ipomoea Ipomoea carnea plant poisoning poisonous plants transmission electron microscopy
spellingShingle	Ciencias Veterinarias CNS lesions Capra hircus goats Ipomoea Ipomoea carnea plant poisoning poisonous plants transmission electron microscopy Ríos, Elvio E. Cholich, Luciana Gimeno, Eduardo Juan Guidi, María Guadalupe Acosta de Pérez, Ofelia C. Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system
topic_facet	Ciencias Veterinarias CNS lesions Capra hircus goats Ipomoea Ipomoea carnea plant poisoning poisonous plants transmission electron microscopy
description	<i>Ipomoea carnea</i> subsp. <i>fistulosa</i>, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goats by <i>Ipomoea</i> carnea in Argentina are here described. Five goats received fresh leaves and stems of <i>Ipomoea</i>. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, difficulty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions. There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear reflex originated hyperreflexia, abnormal posture, head movements and tremors. The withdrawal reflex produced flexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal reflex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in <i>Ipomoea</i>. These clinical signs were correlated with lesions in different parts of the CNS.
format	Articulo Articulo
author	Ríos, Elvio E. Cholich, Luciana Gimeno, Eduardo Juan Guidi, María Guadalupe Acosta de Pérez, Ofelia C.
author_facet	Ríos, Elvio E. Cholich, Luciana Gimeno, Eduardo Juan Guidi, María Guadalupe Acosta de Pérez, Ofelia C.
author_sort	Ríos, Elvio E.
title	Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system
title_short	Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system
title_full	Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system
title_fullStr	Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system
title_full_unstemmed	Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system
title_sort	experimental poisoning of goats by <i>ipomoea carnea</i> subsp. <i>fistulosa</i> in argentina: a clinic and pathological correlation with special consideration on the central nervous system
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/40263 http://www.scielo.br/pdf/pvb/v32n1/v32n1a07.pdf
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Experimental poisoning of goats by <i>Ipomoea carnea</i> subsp. <i>fistulosa</i> in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

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