Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil

An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. Affected calves, after one month of age, showed progressive difficulty to follow...

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Autores principales:	Zlotowski, P., Nakazato, L., Dutra, V., Barros, S. S., Gimeno, Eduardo Juan, Göcks, M., Colodel, E. M., Driemeier, D.
Formato:	Articulo Revision
Lenguaje:	Portugués
Publicado:	2005
Materias:	Ciencias Veterinarias Brasil brahman cattle animalia Bos taurus glycogenosis inherited disease
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/35624 http://www.scielo.br/pdf/pvb/v25n4/a04v25n4.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Portugués
topic	Ciencias Veterinarias Brasil brahman cattle animalia Bos taurus glycogenosis inherited disease
spellingShingle	Ciencias Veterinarias Brasil brahman cattle animalia Bos taurus glycogenosis inherited disease Zlotowski, P. Nakazato, L. Dutra, V. Barros, S. S. Gimeno, Eduardo Juan Göcks, M. Colodel, E. M. Driemeier, D. Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil
topic_facet	Ciencias Veterinarias Brasil brahman cattle animalia Bos taurus glycogenosis inherited disease
description	An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. Affected calves, after one month of age, showed progressive difficulty to follow their mother, retarded growth, muscular weakness and tremors, lethargy and poor body condition. All affected calves were sired by the same bull. Necropsy was performed on three affected calves. The only gross lesion detected was paleness of the skeletal muscles of the trunk and limbs. Cytoplasmic vacuoles, the main histological lesion, were particularly evident in skeletal muscles, myocardium and Purkinje fibers, in neurons of the brain and spinal cord. Large amounts of periodic acid Schiff (PAS) positive granules were also observed in these most severely affected tissues. Pretreatment with diastase completely abolished the PAS reactivity. The 1057?TA, a lethal mutation in the gene of the acid alpha-glucosidase, which causes generalized glycogenosis in Brahman cattle, was detected by PCR in paraffin embedded tissues of affected animals on which post-mortem examination was performed. Clinical, histological and molecular findings were similar to previous descriptions of generalized glycogenosis in Brahman cattle in Australia. No previous indexed reports about generalized glycogenosis of Brahman cattle in Brazil could be found.
format	Articulo Revision
author	Zlotowski, P. Nakazato, L. Dutra, V. Barros, S. S. Gimeno, Eduardo Juan Göcks, M. Colodel, E. M. Driemeier, D.
author_facet	Zlotowski, P. Nakazato, L. Dutra, V. Barros, S. S. Gimeno, Eduardo Juan Göcks, M. Colodel, E. M. Driemeier, D.
author_sort	Zlotowski, P.
title	Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil
title_short	Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil
title_full	Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil
title_fullStr	Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil
title_full_unstemmed	Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil
title_sort	glicogenose hereditária em bovinos brahman no brasil : inherited glycogenosis in brahman cattle in brazil
publishDate	2005
url	http://sedici.unlp.edu.ar/handle/10915/35624 http://www.scielo.br/pdf/pvb/v25n4/a04v25n4.pdf
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Glicogenose hereditária em bovinos Brahman no Brasil : Inherited glycogenosis in Brahman cattle in Brazil

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