Thymic atrophy in cattle poisoned with Solanum glaucophyllum

<i>Solanum glaucophyllum</i> (Sg) [= <i>S. malacoxylon</i>] is a calcinogenic plant inducing "Enzootic Calcinosis" in cattle. The 1,25-dihydroxyvitamin D<SUB>3</SUB>, its main toxic principle, regulates bone and calcium metabolism and also exerts immunom...

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Autores principales: Fontana, Paula Andrea, Zanuzzi, Carolina Natalia, Barbeito, Claudio Gustavo, Gimeno, Eduardo Juan, Portiansky, Enrique Leo
Formato: Articulo
Lenguaje:Portugués
Publicado: 2009
Materias:
Ciencias Veterinarias
animalia
calcinosis
calcitriol
Arachis hypogaea
bos
cattle
immunohistochemistry
lectinhistochemistry
plant poisoning
S. malacoxylon
Solanum glaucophyllum
thymus gland
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/35586
http://www.scielo.br/pdf/pvb/v29n3/14.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-35586
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Portugués
topic Ciencias Veterinarias
animalia
calcinosis
calcitriol
Arachis hypogaea
bos
cattle
immunohistochemistry
lectinhistochemistry
plant poisoning
S. malacoxylon
Solanum glaucophyllum
thymus gland
spellingShingle Ciencias Veterinarias
animalia
calcinosis
calcitriol
Arachis hypogaea
bos
cattle
immunohistochemistry
lectinhistochemistry
plant poisoning
S. malacoxylon
Solanum glaucophyllum
thymus gland
Fontana, Paula Andrea
Zanuzzi, Carolina Natalia
Barbeito, Claudio Gustavo
Gimeno, Eduardo Juan
Portiansky, Enrique Leo
Thymic atrophy in cattle poisoned with Solanum glaucophyllum
topic_facet Ciencias Veterinarias
animalia
calcinosis
calcitriol
Arachis hypogaea
bos
cattle
immunohistochemistry
lectinhistochemistry
plant poisoning
S. malacoxylon
Solanum glaucophyllum
thymus gland
description <i>Solanum glaucophyllum</i> (Sg) [= <i>S. malacoxylon</i>] is a calcinogenic plant inducing "Enzootic Calcinosis" in cattle. The 1,25-dihydroxyvitamin D<SUB>3</SUB>, its main toxic principle, regulates bone and calcium metabolism and also exerts immunomodulatory effects. Thymocyte precursors from bone marrow-derived progenitor cells differentiate into mature T-cells. Differentiation of most T lymphocytes is characterized not only by the variable expression of CD4/CD8 receptor molecules and increased surface density of the T cell antigen receptor, but also by changes in the glycosylation pattern of cell surface glycolipids or glycoproteins. Thymocytes exert a feedback influence on thymic non-lymphoid cells. Sg-induced modifications on cattle thymus T-lymphocytes and on non-lymphoid cells were analysed. Heifers were divided into 5 groups (control, intoxicated with Sg during 15, 30 or 60 days, and probably recovered group). Histochemical, immunohistochemical, lectinhistochemical and morphometric techniques were used to characterize different cell populations of the experimental heifers. Sg-poisoned heifers showed a progressive cortical atrophy that was characterized using the peanut agglutinin (PNA) lectin that recognizes immature thymocytes. These animals also increased the amount of non-lymphoid cells per unit area detected with the Picrosirius technique, WGA and DBA lectins, and pancytokeratin and S-100 antibodies. The thymus atrophy found in intoxicated animals resembled that of the physiological aging process. A reversal effect on these changes was observed after suppression of the intoxication. These findings suggest that Sg-intoxication induces either directly, through the 1,25-dihydroxyvitamin D<SUB>3</SUB> itself, or indirectly through the hypercalcemia, the observed alteration of the thymus.
format Articulo
Articulo
author Fontana, Paula Andrea
Zanuzzi, Carolina Natalia
Barbeito, Claudio Gustavo
Gimeno, Eduardo Juan
Portiansky, Enrique Leo
author_facet Fontana, Paula Andrea
Zanuzzi, Carolina Natalia
Barbeito, Claudio Gustavo
Gimeno, Eduardo Juan
Portiansky, Enrique Leo
author_sort Fontana, Paula Andrea
title Thymic atrophy in cattle poisoned with Solanum glaucophyllum
title_short Thymic atrophy in cattle poisoned with Solanum glaucophyllum
title_full Thymic atrophy in cattle poisoned with Solanum glaucophyllum
title_fullStr Thymic atrophy in cattle poisoned with Solanum glaucophyllum
title_full_unstemmed Thymic atrophy in cattle poisoned with Solanum glaucophyllum
title_sort thymic atrophy in cattle poisoned with solanum glaucophyllum
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/35586
http://www.scielo.br/pdf/pvb/v29n3/14.pdf
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