Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures

In this review we provide a systematic analysis of transcriptomic signatures derived from 42 breast cancer gene expression studies, in an effort to identify the most relevant breast cancer biomarkers using a meta-analysis method. Meta-data revealed a set of 117 genes that were the most commonly affe...

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Detalles Bibliográficos
Autores principales:	Abba, Martín Carlos, Lacunza, Ezequiel, Butti, Matías A., Aldaz, C. Marcelo
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2010
Materias:	Ciencias Médicas biomarkers APC protein aurora A kinase breast cancer Bub1 related protein gene expression signatures cyclin estrogen receptor alpha forkhead transcription factor hepatocyte nuclear factor 3alpha manganese superoxide dismutase TTK protein kinase ubiquitin conjugating enzyme microarray analysis mitosis spindle
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/34620 http://www.la-press.com/breast-cancer-biomarker-discovery-in-the-functional-genomic-age-a-syst-article-a2325
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-34620
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas biomarkers APC protein aurora A kinase breast cancer Bub1 related protein gene expression signatures cyclin estrogen receptor alpha forkhead transcription factor hepatocyte nuclear factor 3alpha manganese superoxide dismutase TTK protein kinase ubiquitin conjugating enzyme microarray analysis mitosis spindle
spellingShingle	Ciencias Médicas biomarkers APC protein aurora A kinase breast cancer Bub1 related protein gene expression signatures cyclin estrogen receptor alpha forkhead transcription factor hepatocyte nuclear factor 3alpha manganese superoxide dismutase TTK protein kinase ubiquitin conjugating enzyme microarray analysis mitosis spindle Abba, Martín Carlos Lacunza, Ezequiel Butti, Matías A. Aldaz, C. Marcelo Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures
topic_facet	Ciencias Médicas biomarkers APC protein aurora A kinase breast cancer Bub1 related protein gene expression signatures cyclin estrogen receptor alpha forkhead transcription factor hepatocyte nuclear factor 3alpha manganese superoxide dismutase TTK protein kinase ubiquitin conjugating enzyme microarray analysis mitosis spindle
description	In this review we provide a systematic analysis of transcriptomic signatures derived from 42 breast cancer gene expression studies, in an effort to identify the most relevant breast cancer biomarkers using a meta-analysis method. Meta-data revealed a set of 117 genes that were the most commonly affected ranging from 12% to 36% of overlap among breast cancer gene expression studies. Data mining analysis of transcripts and protein-protein interactions of these commonly modulated genes indicate three functional modules signifcantly affected among signatures, one module related with the response to steroid hormone stimulus, and two modules related to the cell cycle. Analysis of a publicly available gene expression data showed that the obtained meta-signature is capable of predicting overall survival (P < 0.0001) and relapse-free survival (P < 0.0001) in patients with early-stage breast carcinomas. In addition, the identifed meta-signature improves breast cancer patient stratifcation independently of traditional prognostic factors in a multivariate Cox proportional-hazards analysis.
format	Articulo Revision
author	Abba, Martín Carlos Lacunza, Ezequiel Butti, Matías A. Aldaz, C. Marcelo
author_facet	Abba, Martín Carlos Lacunza, Ezequiel Butti, Matías A. Aldaz, C. Marcelo
author_sort	Abba, Martín Carlos
title	Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures
title_short	Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures
title_full	Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures
title_fullStr	Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures
title_full_unstemmed	Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures
title_sort	breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/34620 http://www.la-press.com/breast-cancer-biomarker-discovery-in-the-functional-genomic-age-a-syst-article-a2325
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Breast cancer biomarker discovery in the functional genomic age: A systematic review of 42 gene expression signatures

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