Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization

Hemodynamic care during postoperative management of myocardial revascularization should include vasorelaxing drugs to insure adequate graft and coronary flow, and stimulation of stroke volume to maintain vascular perfusion pressure. We tested the cardiac (inotropic and lusitropic) and vascular (rela...

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Autores principales: Gómez Alvis, Alicia, Rebolledo, Alejandro, Milesi, Verónica, Raingo, Jesica, Sanz, Nora, Tommasi, Juan J., Drago, Adolfo, Rinaldi, Gustavo, Grassi de Gende, Ángela
Formato: Articulo
Lenguaje:Inglés
Publicado: 2004
Materias:
Ciencias Exactas
Biología
Amrinona
Dobutamina
Diltiazem
Vena Safena
Arterias Mamarias
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/29738
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2004000600015&lng=en&nrm=iso&tlng=en
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-29738
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Biología
Amrinona
Dobutamina
Diltiazem
Vena Safena
Arterias Mamarias
spellingShingle Ciencias Exactas
Biología
Amrinona
Dobutamina
Diltiazem
Vena Safena
Arterias Mamarias
Gómez Alvis, Alicia
Rebolledo, Alejandro
Milesi, Verónica
Raingo, Jesica
Sanz, Nora
Tommasi, Juan J.
Drago, Adolfo
Rinaldi, Gustavo
Grassi de Gende, Ángela
Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
topic_facet Ciencias Exactas
Biología
Amrinona
Dobutamina
Diltiazem
Vena Safena
Arterias Mamarias
description Hemodynamic care during postoperative management of myocardial revascularization should include vasorelaxing drugs to insure adequate graft and coronary flow, and stimulation of stroke volume to maintain vascular perfusion pressure. We tested the cardiac (inotropic and lusitropic) and vascular (relaxant) effects of diltiazem (0.1 nM to 0.1 mM), dobutamine (10 μM to 10 mM) and amrinone (10 μM to 1 mM) on isolated rat atria and thoracic aorta, and also on isolated human saphenous vein (HSV) and human mammary artery (HMA). Dobutamine produced a maximal positive inotropic effect (+dF/dtmax = 29 ± 7%) at its ED50 for aortic relaxation (88 ± 7 μM). Conversely, at their ED50 for aortic relaxation diltiazem depressed myocardial contractility and amrinone did not exhibit myocardial effects. In HSV and HMA contracted with 80 mM potassium, diltiazem and dobutamine (but not amrinone) had a vasorelaxant activity similar to that in rat aorta. Norepinephrine-contracted human vessels were significantly more sensitive than potassium-contracted vessels to the relaxant effect of amrinone (ED50 HMA = 15 ± 5 μM, ED50 HSV = 72 ± 31 μM, P < 0.05). We conclude that at concentrations still devoid of myocardial effects dobutamine and amrinone are effective dilators in graft segment vessels and rat aorta contracted by membrane depolarization. If the difference between aortic and myocardial tissue still holds in human tissues, at the appropriate concentrations these drugs should be expected to improve cardiac performance while still contributing to the maintenance of graft patency.
format Articulo
Articulo
author Gómez Alvis, Alicia
Rebolledo, Alejandro
Milesi, Verónica
Raingo, Jesica
Sanz, Nora
Tommasi, Juan J.
Drago, Adolfo
Rinaldi, Gustavo
Grassi de Gende, Ángela
author_facet Gómez Alvis, Alicia
Rebolledo, Alejandro
Milesi, Verónica
Raingo, Jesica
Sanz, Nora
Tommasi, Juan J.
Drago, Adolfo
Rinaldi, Gustavo
Grassi de Gende, Ángela
author_sort Gómez Alvis, Alicia
title Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
title_short Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
title_full Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
title_fullStr Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
title_full_unstemmed Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
title_sort cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
publishDate 2004
url http://sedici.unlp.edu.ar/handle/10915/29738
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2004000600015&lng=en&nrm=iso&tlng=en
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