Increased number of neurons in the cervical spinal cord of aged female rats

In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that generate new neurons in adulthood. Much less is known about the spinal cord where a sustained adult neurogenesis is not observed. Moreover,...

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Autores principales: Portiansky, Enrique Leo, Nishida, Fabián, Barbeito, Claudio Gustavo, Gimeno, Eduardo Juan, Goya, Rodolfo Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Ciencias Veterinarias
Neuronas
Médula Espinal
Neurogénesis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/29562
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022537
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-29562
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Neuronas
Médula Espinal
Neurogénesis
spellingShingle Ciencias Veterinarias
Neuronas
Médula Espinal
Neurogénesis
Portiansky, Enrique Leo
Nishida, Fabián
Barbeito, Claudio Gustavo
Gimeno, Eduardo Juan
Goya, Rodolfo Gustavo
Increased number of neurons in the cervical spinal cord of aged female rats
topic_facet Ciencias Veterinarias
Neuronas
Médula Espinal
Neurogénesis
description In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that generate new neurons in adulthood. Much less is known about the spinal cord where a sustained adult neurogenesis is not observed. Moreover, there is scarce information concerning cell proliferation in the adult mammalian spinal cord and virtually none in aging animals or humans. We performed a comparative morphometric and immunofluorescence study of the entire cervical region (C1-C8) in young (5 mo.) and aged (30 mo.) female rats. Serum prolactin (PRL), a neurogenic hormone, was also measured. Gross anatomy showed a significant age-related increase in size of all of the cervical segments. Morphometric analysis of cresyl violet stained segments also showed a significant increase in the area occupied by the gray matter of some cervical segments of aged rats. The most interesting finding was that both the total area occupied by neurons and the number of neurons increased significantly with age, the latter increase ranging from 16% (C6) to 34% (C2). Taking the total number of cervical neurons the age-related increase ranged from 19% (C6) to 51% (C3), C3 being the segment that grew most in length in the aged animals. Some bromodeoxyuridine positive-neuron specific enolase negative (BrdU +-NSE -) cells were observed and, occasionally, double positive (BrdU +-NSE +) cells were detected in some cervical segments of both young and aged rats groups. As expected, serum PRL increased markedly with age. We propose that in the cervical spinal cord of female rats, both maturation of pre-existing neuroblasts and/or possible neurogenesis occur during the entire life span, in a process in which PRL may play a role. © 2011 Portiansky et al.
format Articulo
Articulo
author Portiansky, Enrique Leo
Nishida, Fabián
Barbeito, Claudio Gustavo
Gimeno, Eduardo Juan
Goya, Rodolfo Gustavo
author_facet Portiansky, Enrique Leo
Nishida, Fabián
Barbeito, Claudio Gustavo
Gimeno, Eduardo Juan
Goya, Rodolfo Gustavo
author_sort Portiansky, Enrique Leo
title Increased number of neurons in the cervical spinal cord of aged female rats
title_short Increased number of neurons in the cervical spinal cord of aged female rats
title_full Increased number of neurons in the cervical spinal cord of aged female rats
title_fullStr Increased number of neurons in the cervical spinal cord of aged female rats
title_full_unstemmed Increased number of neurons in the cervical spinal cord of aged female rats
title_sort increased number of neurons in the cervical spinal cord of aged female rats
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/29562
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022537
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