Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups

The conventional method for preparing chitosan nanoparticles (CS-NPs) leads to the surface amino groups protonated and unable to link other useful moieties. In this study, we optimized the method of sodium chloride precipitation our lab established before to produce CS-NPs with surface free amino gr...

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Detalles Bibliográficos
Autores principales: Yao, Qian, Gan, Liangchun, Hou, Shixiang, Guo, Xiaoqiang, Yan, Jun, Song, Qin, Gou, Xiaojun
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Biodistribution
Chitosan nanoparticles
Free amino groups
Liver
Pharmacokinetics
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25753
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_17.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25753
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Biodistribution
Chitosan nanoparticles
Free amino groups
Liver
Pharmacokinetics
spellingShingle Farmacia
Biodistribution
Chitosan nanoparticles
Free amino groups
Liver
Pharmacokinetics
Yao, Qian
Gan, Liangchun
Hou, Shixiang
Guo, Xiaoqiang
Yan, Jun
Song, Qin
Gou, Xiaojun
Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
topic_facet Farmacia
Biodistribution
Chitosan nanoparticles
Free amino groups
Liver
Pharmacokinetics
description The conventional method for preparing chitosan nanoparticles (CS-NPs) leads to the surface amino groups protonated and unable to link other useful moieties. In this study, we optimized the method of sodium chloride precipitation our lab established before to produce CS-NPs with surface free amino groups. The effects of preparation conditions on the size and encapsulation efficiency were examined. As surface amino groups may exert special effect on the NPs biodistribution, in vivo distribution was investigated after intravenous administration to the mice. The optimized CS-NPs were round with the mean diameter of 257 ± 21 nm. Compared with trans-resveratrol solution, the CS-NPs had longer circulation time in vivo. The AUC of CS-NPs in liver was 2.29 fold AUC of the solution. This study demonstrates that not only can the unique CS-NPs be modified to obtain active targeting systems, they are also an excellent candidate for liver targeting treatment.
format Articulo
Articulo
author Yao, Qian
Gan, Liangchun
Hou, Shixiang
Guo, Xiaoqiang
Yan, Jun
Song, Qin
Gou, Xiaojun
author_facet Yao, Qian
Gan, Liangchun
Hou, Shixiang
Guo, Xiaoqiang
Yan, Jun
Song, Qin
Gou, Xiaojun
author_sort Yao, Qian
title Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
title_short Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
title_full Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
title_fullStr Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
title_full_unstemmed Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
title_sort development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25753
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_17.pdf
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