Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats
In this study, the impacts of adrenalin on ovarian injury caused by ischemia reperfusion were investigated in rats. In addition, it’s been investigated whether there is a correlation between adrenergic receptors and oxidant/anti-oxidant and COX1/COX-2 levels. It’s been observed that the COX-2 level...
| Autores principales: | , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25752 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_16.pdf |
| Aporte de: |
| id |
I19-R120-10915-25752 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Adrenalin COX1/COX-2 levels Ischemia reperfusion Ovarian injury Rats |
| spellingShingle |
Farmacia Adrenalin COX1/COX-2 levels Ischemia reperfusion Ovarian injury Rats Yilmaz, Mehmet Ozgeris, Fatma B. Isaoglu, Unal Cetin, Nihal Turan, Mehmet I. Suleyman, Bahadir Gocer, Fatma Suleyman, Halis Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| topic_facet |
Farmacia Adrenalin COX1/COX-2 levels Ischemia reperfusion Ovarian injury Rats |
| description |
In this study, the impacts of adrenalin on ovarian injury caused by ischemia reperfusion were investigated in rats. In addition, it’s been investigated whether there is a correlation between adrenergic receptors and oxidant/anti-oxidant and COX1/COX-2 levels. It’s been observed that the COX-2 level that is responsible for MDA and inflammatory reaction (which are the indicators of oxidative stress in ovarian tissue to which ischemia reperfusion was applied) increased and the COX-1 levels that are responsible for GSH (an endogenic anti-oxidant with protective impact) were depressed. Adrenalin has prevented an increase in MDA and COX-2 activity in the ovarian tissue, to which I/R was applied, and prevented a reduction in GSH and COX-1 activity. However, adrenalin failed to prevent an MDA increase in ovarian tissue, to which alpha-2 adrenergic receptor blocker yohimbine was given (I/R formed), and also failed to prevent a GSH and COX-1 decrease. Adrenalin also failed to inhibit the COX-2 activity increase in ovarian tissue, to which beta blocker was applied. As a result, stimulation of the alpha-2 adrenergic receptors in an ovarian tissue causes an anti-oxidant and protective effect, while stimulation of beta-2 adrenergic receptors causes an anti-inflammatory effect. It’s been thought that adrenalin protects the ovarian tissue against ischemia reperfusion by stimulating the alpha-2 and beta-2 adrenergic receptors. |
| format |
Articulo Articulo |
| author |
Yilmaz, Mehmet Ozgeris, Fatma B. Isaoglu, Unal Cetin, Nihal Turan, Mehmet I. Suleyman, Bahadir Gocer, Fatma Suleyman, Halis |
| author_facet |
Yilmaz, Mehmet Ozgeris, Fatma B. Isaoglu, Unal Cetin, Nihal Turan, Mehmet I. Suleyman, Bahadir Gocer, Fatma Suleyman, Halis |
| author_sort |
Yilmaz, Mehmet |
| title |
Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| title_short |
Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| title_full |
Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| title_fullStr |
Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| title_full_unstemmed |
Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| title_sort |
effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/25752 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_16.pdf |
| work_keys_str_mv |
AT yilmazmehmet effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT ozgerisfatmab effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT isaogluunal effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT cetinnihal effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT turanmehmeti effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT suleymanbahadir effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT gocerfatma effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats AT suleymanhalis effectsofadrenalinonovarianinjuryformedbyischemiareperfusioninrats |
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Repositorios |
| _version_ |
1764820466910887937 |