Protective effects of luteolin on restraint stress-induced liver damage in mice

The present study was designed to investigate the protective effects of luteolin, a flavonoid, against acute immobilization-induced liver damage in mice. Mice were immobilized for a period of 6 h daily for three consecutive weeks. Luteolin (25 or 100 mg/kg, i.g.) was administered 30 min before subje...

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Autores principales: Liu, Yi, Ling, Xin, Gou, Lingshang, Fu, Xiaobin, Li, Sai, Lan, Nuo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Liver damage
Luteolin
Oxidative stress
Restraint stress
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25751
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25751
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Liver damage
Luteolin
Oxidative stress
Restraint stress
spellingShingle Farmacia
Liver damage
Luteolin
Oxidative stress
Restraint stress
Liu, Yi
Ling, Xin
Gou, Lingshang
Fu, Xiaobin
Li, Sai
Lan, Nuo
Protective effects of luteolin on restraint stress-induced liver damage in mice
topic_facet Farmacia
Liver damage
Luteolin
Oxidative stress
Restraint stress
description The present study was designed to investigate the protective effects of luteolin, a flavonoid, against acute immobilization-induced liver damage in mice. Mice were immobilized for a period of 6 h daily for three consecutive weeks. Luteolin (25 or 100 mg/kg, i.g.) was administered 30 min before subjecting the animals to restraint stress (RS). Our experiment showed that RS could induce liver damage, with an increase in glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) in the liver tissue. Furthermore, the changes of anti-oxidative capacity in liver tissue were also measured. The changes of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and catalase activities (CAT) of stress group were significantly different from those in the control group. However, these changes in stress low and high-doses of luteolin modulation group were improved. These results demonstrated that luteolin has a protective effect against RS-induced liver damage through scavenging both free radicals activity and lipid peroxidation inhibitory effect.
format Articulo
Articulo
author Liu, Yi
Ling, Xin
Gou, Lingshang
Fu, Xiaobin
Li, Sai
Lan, Nuo
author_facet Liu, Yi
Ling, Xin
Gou, Lingshang
Fu, Xiaobin
Li, Sai
Lan, Nuo
author_sort Liu, Yi
title Protective effects of luteolin on restraint stress-induced liver damage in mice
title_short Protective effects of luteolin on restraint stress-induced liver damage in mice
title_full Protective effects of luteolin on restraint stress-induced liver damage in mice
title_fullStr Protective effects of luteolin on restraint stress-induced liver damage in mice
title_full_unstemmed Protective effects of luteolin on restraint stress-induced liver damage in mice
title_sort protective effects of luteolin on restraint stress-induced liver damage in mice
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25751
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_15.pdf
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