Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer

The objectives of this study were to develop and characterize the matrix type transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH). The matrix patch contains different ratios of Eudragit RS 100 and polyvinyl pyrrolidone (PVP) with different concentrations of plasticizer like tr...

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Autores principales: Rajabalaya, Rajan, David, Sheba R.N., Xian, Tan W.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Ondansetron hydrochloride
Plasticizers
Transdermal
Vegetable oils
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25746
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25746
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Ondansetron hydrochloride
Plasticizers
Transdermal
Vegetable oils
spellingShingle Farmacia
Ondansetron hydrochloride
Plasticizers
Transdermal
Vegetable oils
Rajabalaya, Rajan
David, Sheba R.N.
Xian, Tan W.
Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
topic_facet Farmacia
Ondansetron hydrochloride
Plasticizers
Transdermal
Vegetable oils
description The objectives of this study were to develop and characterize the matrix type transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH). The matrix patch contains different ratios of Eudragit RS 100 and polyvinyl pyrrolidone (PVP) with different concentrations of plasticizer like triethyl citrate (TEC) and dibutyl sebacate (DBS) as well as vegetable oils such as linseed oil, castor oil and eugenol were added and prepared by solvent casting method. Thickness, tensile strength, drug content, moisture content and water absorption studies of the matrix patches were measured. The in vitro drug release and permeation studies were carried out in Franz diffusion cell. The percentage of drug release increased with increasing amounts of PVP and plasticizer, whereas DBS containing patches exhibited higher than TEC containing patches. It may conclude that transdermal patches which use Eudragit RS 100 as the base polymer with higher amount of PVP and plasticizer DBS and additions of linseed oil were suitable for the development of ODH transdermal patches.
format Articulo
Articulo
author Rajabalaya, Rajan
David, Sheba R.N.
Xian, Tan W.
author_facet Rajabalaya, Rajan
David, Sheba R.N.
Xian, Tan W.
author_sort Rajabalaya, Rajan
title Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
title_short Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
title_full Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
title_fullStr Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
title_full_unstemmed Preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
title_sort preparation and evaluation of transdermal drug delivery of ondansetron hydrochloride: effect of vegetable oils as permeation enhancer
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25746
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_12.pdf
work_keys_str_mv AT rajabalayarajan preparationandevaluationoftransdermaldrugdeliveryofondansetronhydrochlorideeffectofvegetableoilsaspermeationenhancer
AT davidshebarn preparationandevaluationoftransdermaldrugdeliveryofondansetronhydrochlorideeffectofvegetableoilsaspermeationenhancer
AT xiantanw preparationandevaluationoftransdermaldrugdeliveryofondansetronhydrochlorideeffectofvegetableoilsaspermeationenhancer
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