Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves

The present study investigated the antidepressant-like effect of hyperoside extracted from Apocynum venetum leaves in mice using the tail suspension test (TST) and forced swimming test (FST). Hyperoside administration at 10, 20 and 30 mg/kg (p.o.) for 10 days reduced immobility time in both tests....

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Autores principales:	Zheng, Meiqin, Liu, Chunming, Fan, Yajun, Shi, Dongfang
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Antidepressant-like effect Apocynum venetum Hyperoside
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/25742 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_9.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-25742
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Antidepressant-like effect Apocynum venetum Hyperoside
spellingShingle	Farmacia Antidepressant-like effect Apocynum venetum Hyperoside Zheng, Meiqin Liu, Chunming Fan, Yajun Shi, Dongfang Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
topic_facet	Farmacia Antidepressant-like effect Apocynum venetum Hyperoside
description	The present study investigated the antidepressant-like effect of hyperoside extracted from Apocynum venetum leaves in mice using the tail suspension test (TST) and forced swimming test (FST). Hyperoside administration at 10, 20 and 30 mg/kg (p.o.) for 10 days reduced immobility time in both tests. This effect is dose-dependent without influencing the animals’ locomotor activity. Additionally, the monoaminergic mechanisms involved in the antidepressant-like effect of hyperoside in the mouse forced swimming test (FST) were evaluated. The results showed that hyperoside produced an antidepressant-like effect in the FST (10-30 mg/kg, i.g.) and in the TST (10–30 mg/kg, i.g.), without accompanying changes in ambulation distance when assessed in the open-ﬁeld test. The antidepressant-like effect of hyperoside (20 mg/kg, i.g.) was prevented by the pretreatment of mice with ketanserin (5 mg/kg, s.c., a serotonin 5-HT2A receptor antagonist), cyproheptadine (3 mg/kg, i.g., a serotonin 5-HT2 receptor antagonist). On the other hand, the pretreatment of mice with WAY 100635 (0.1 mg/kg, s.c., a serotonin 5-HT1A receptor antagonist) did not block the antidepressant-like effect of hyperoside in the TST. It may be concluded that the hyperoside produces an antidepressant-like effect in the FST and in the TST that is dependent on its interaction with the serotonergic (5-HT2A and 5-HT2 receptors) systems. Taken together, our results suggested that hyperoside deserves further investigation as a putative alternative therapeutic tool that could help the conventional pharmacotherapy of depression.
format	Articulo Articulo
author	Zheng, Meiqin Liu, Chunming Fan, Yajun Shi, Dongfang
author_facet	Zheng, Meiqin Liu, Chunming Fan, Yajun Shi, Dongfang
author_sort	Zheng, Meiqin
title	Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
title_short	Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
title_full	Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
title_fullStr	Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
title_full_unstemmed	Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
title_sort	involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/25742 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_9.pdf
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bdutipo_str	Repositorios
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Involvement of serotonergic system in the antidepressant-like effect of hyperoside from apocynum venetum leaves

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