Marine sponges of the genus neopetrosia with anti-inflammatory activity
The present study aimed to investigate the anti-inflammatory effect of marine sponges of the genus Neopetrosia which are abundant in the Colombian Caribbean. We obtained three fractions from a total methanolic extract of Neopetrosia rosariensis and proxima. In vivo activity was measured using λ-carr...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25741 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_8.pdf |
| Aporte de: |
| Sumario: | The present study aimed to investigate the anti-inflammatory effect of marine sponges of the genus Neopetrosia which are abundant in the Colombian Caribbean. We obtained three fractions from a total methanolic extract of Neopetrosia rosariensis and proxima. In vivo activity was measured using λ-carrageenan-induced paw edema assay. The in vitro inhibitory effects were evaluated on myeloperoxidase activity (MPO) and nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor alpha (TNF- α) production. Total extracts of N. rosariensis and N. proxima (100 mg/Kg) significantly inhibited the paw edema of rats (71.74% and 60.06%, respectively). Dichloromethane and methanol fractions of Neopetrosia sponges reduced MPO activity. Only, dichloromethane fraction of N. rosariensis significantly inhibited NO (66%), PGE2 (30.5%) and TNF-α production (72%). Our results show anti-inflammatory activity in extracts and fractions from species of marine sponges belonging to Neopetrosia genus and open the way for complementary studies to purify and identify active molecules. |
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