Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats

This study investigated the anti-proteinuric effect of sulodexide in rats with adriamycin (ADR) nephropathy. A total of 40 healthy male Sprague-Dawley (SD) rats were randomly assigned to four groups: normal control group (Control-group), ADR control group (ADR-group), sulodexide treatment group (SUL...

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Autores principales: Chen, Zhibin, Zhu, Lihe, Zhen, Yangming, Li, Dan, Tang, Busheng, Chen, Wenhai, Hu, Lufeng
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Adriamycin nephropathy
Losartan
Rat
Sulodexide
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25739
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25739
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Adriamycin nephropathy
Losartan
Rat
Sulodexide
spellingShingle Farmacia
Adriamycin nephropathy
Losartan
Rat
Sulodexide
Chen, Zhibin
Zhu, Lihe
Zhen, Yangming
Li, Dan
Tang, Busheng
Chen, Wenhai
Hu, Lufeng
Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
topic_facet Farmacia
Adriamycin nephropathy
Losartan
Rat
Sulodexide
description This study investigated the anti-proteinuric effect of sulodexide in rats with adriamycin (ADR) nephropathy. A total of 40 healthy male Sprague-Dawley (SD) rats were randomly assigned to four groups: normal control group (Control-group), ADR control group (ADR-group), sulodexide treatment group (SUL-group), and losartan treatment group (LOS-group). The ADR-induced rat models were established by injecting two different doses of ADR (4 and 3.5 mg/kg) into the caudal vein of rat for two consecutive weeks. After that, SUL-group and LOS-group were respectively treated with sulodexide (10 mg/kg/day) and losartan (10 mg/kg/day) for an additional 4 weeks period. Samples of 24-hour urine were harvested at 3, 4, 5, and 6 weeks after the model establishment. The pathological change in renal tissues was observed by light microscopy, the function of liver and kidney were assayed at week 6th . The results showed that the urinary excretion of protein progressively increased in ADR-group, and accompanied with severe nephrotic syndrome such as massive albuminuria, proteinuria, and hyperlipidemia. Sulodexide effectively reduced the 24-hour urinary protein excretion of ADR-induced nephropathy rats, preventing focal segmental glomerulosclerosis. There was no significant difference between LOS-group and SULgroup for reducing urinary protein excretion (P < 0.05). Sulodexide alleviated ADR-induced nephrotoxicity as good as losartan in a short period of treatment.
format Articulo
Articulo
author Chen, Zhibin
Zhu, Lihe
Zhen, Yangming
Li, Dan
Tang, Busheng
Chen, Wenhai
Hu, Lufeng
author_facet Chen, Zhibin
Zhu, Lihe
Zhen, Yangming
Li, Dan
Tang, Busheng
Chen, Wenhai
Hu, Lufeng
author_sort Chen, Zhibin
title Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
title_short Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
title_full Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
title_fullStr Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
title_full_unstemmed Anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
title_sort anti-proteinuric effect of sulodexide in adriamycin-induced nephropathy rats
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25739
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_6.pdf
work_keys_str_mv AT chenzhibin antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
AT zhulihe antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
AT zhenyangming antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
AT lidan antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
AT tangbusheng antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
AT chenwenhai antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
AT hulufeng antiproteinuriceffectofsulodexideinadriamycininducednephropathyrats
bdutipo_str Repositorios
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