Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
In order to reduce the recrystallinity of poorly insoluble drug nelfinavir, PEG 6000 blends were prepared by spray drying with HPMC. The maximal reduction of recrystallinity in PEG 6000 was obtained by co-spray drying with HPMC as revealed by in vitro dissolution studies. The resulting ternary so...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25734 http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_2.pdf |
| Aporte de: |
| Sumario: | In order to reduce the recrystallinity of poorly insoluble drug nelfinavir, PEG 6000 blends
were prepared by spray drying with HPMC. The maximal reduction of recrystallinity in PEG 6000 was
obtained by co-spray drying with HPMC as revealed by in vitro dissolution studies. The resulting ternary
solid dispersions containing nelfinavir were characterized. The results of this study show that addition of
PEG 6000 to nelfinavir/HPMC system leads to extended release of nelfinavir that in most cases recrystallizes indicated by reduction in solubility. For all ternary dispersions containing 20 % of nelfinavir, the
drug was highly amorphous and dissolution was improved compared to binary 20/80 w/w
nelfinavir/HPMC solid dispersion. For all ternary dispersions containing 40 % of nelfinavir, the drug indicated slower and consistent release over a prolonged time, without recrystallization. These results show
that provided nelfinavir is highly amorphous, addition of PEG 6000 to HPMC leads to an extension of
drug release. |
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