Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying

In order to reduce the recrystallinity of poorly insoluble drug nelfinavir, PEG 6000 blends were prepared by spray drying with HPMC. The maximal reduction of recrystallinity in PEG 6000 was obtained by co-spray drying with HPMC as revealed by in vitro dissolution studies. The resulting ternary so...

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Detalles Bibliográficos
Autores principales: Barik, B. B., Dewani, Sunil P.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Differential scanning calorimetry
HPMC
Nelfinavir
PEG 6000
Solid dispersion
Spray drying
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25734
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25734
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Differential scanning calorimetry
HPMC
Nelfinavir
PEG 6000
Solid dispersion
Spray drying
spellingShingle Farmacia
Differential scanning calorimetry
HPMC
Nelfinavir
PEG 6000
Solid dispersion
Spray drying
Barik, B. B.
Dewani, Sunil P.
Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
topic_facet Farmacia
Differential scanning calorimetry
HPMC
Nelfinavir
PEG 6000
Solid dispersion
Spray drying
description In order to reduce the recrystallinity of poorly insoluble drug nelfinavir, PEG 6000 blends were prepared by spray drying with HPMC. The maximal reduction of recrystallinity in PEG 6000 was obtained by co-spray drying with HPMC as revealed by in vitro dissolution studies. The resulting ternary solid dispersions containing nelfinavir were characterized. The results of this study show that addition of PEG 6000 to nelfinavir/HPMC system leads to extended release of nelfinavir that in most cases recrystallizes indicated by reduction in solubility. For all ternary dispersions containing 20 % of nelfinavir, the drug was highly amorphous and dissolution was improved compared to binary 20/80 w/w nelfinavir/HPMC solid dispersion. For all ternary dispersions containing 40 % of nelfinavir, the drug indicated slower and consistent release over a prolonged time, without recrystallization. These results show that provided nelfinavir is highly amorphous, addition of PEG 6000 to HPMC leads to an extension of drug release.
format Articulo
Articulo
author Barik, B. B.
Dewani, Sunil P.
author_facet Barik, B. B.
Dewani, Sunil P.
author_sort Barik, B. B.
title Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
title_short Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
title_full Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
title_fullStr Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
title_full_unstemmed Tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
title_sort tailoring binary and tertiary solid dispersion compositions of nelfinavir using spray drying
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25734
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_2.pdf
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