Antibacterial activity and toxicity of drimys brasiliensis

Men have used medicinal plant properties to treat infectious diseases. Both the rise of emerging infectious diseases as the microbial resistance problem has stimulated the searching for new antimicrobial agents. This study evaluated the antibacterial activity and toxicity of crude extracts, fraction...

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Autores principales: Silveira, Alessandro C.O., Claudino, Vanessa D., Yunes, Rosendo Augusto, Cechinel Filho, Valdir, Malheiro, Angela, Cordova, Caio M.M., Bella Cruz, Alexandre
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Artemia salina
Drimys brasiliensis
Helicobacter pylori
Minimum inhibitory concentration
Toxicity
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25733
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25733
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Artemia salina
Drimys brasiliensis
Helicobacter pylori
Minimum inhibitory concentration
Toxicity
spellingShingle Farmacia
Artemia salina
Drimys brasiliensis
Helicobacter pylori
Minimum inhibitory concentration
Toxicity
Silveira, Alessandro C.O.
Claudino, Vanessa D.
Yunes, Rosendo Augusto
Cechinel Filho, Valdir
Malheiro, Angela
Cordova, Caio M.M.
Bella Cruz, Alexandre
Antibacterial activity and toxicity of drimys brasiliensis
topic_facet Farmacia
Artemia salina
Drimys brasiliensis
Helicobacter pylori
Minimum inhibitory concentration
Toxicity
description Men have used medicinal plant properties to treat infectious diseases. Both the rise of emerging infectious diseases as the microbial resistance problem has stimulated the searching for new antimicrobial agents. This study evaluated the antibacterial activity and toxicity of crude extracts, fractions and pure compounds from Drimys brasiliensis. The antibacterial activity of five extracts, twelve fractions and five isolated compounds were tested against six Gram-positive and seven Gram-negative bacteria. The methodology used was agar dilution. The extract potential toxicities were evaluated using Artemia salina assay. Antibacterial activity tests showed some promising results, such as bark chloroform extract with minimum inhibitory concentration (MIC) of 62.5 μg/mL for Bacillus cereus, fraction G2 with MIC for Staphylococcus aureus of 62.5 μg/mL, and methoxy-polygodial compound with MIC to Bacillus cereus of 31.25 μg/mL. There was no activity against Gram-negative bacteria. The bark dichloromethane extract showed MIC of 1000 μg/mL against Helicobacter pylori. The best results corresponded to fractions E and G2, with a MIC of 500 μg/mL. Among the isolated compounds, polygodial showed better activity with MIC of 250 μg/mL. Artemia salina tests showed that the bark dichloromethane extract and the fractions E and G2 showed toxicity, with LC50 values of 27.51, 25.29 and 139.7 μg/mL, respectively. The results showed the antibacterial activity of Drimys brasiliensis, with potential toxicity, but with possible antimutagenic action.
format Articulo
Articulo
author Silveira, Alessandro C.O.
Claudino, Vanessa D.
Yunes, Rosendo Augusto
Cechinel Filho, Valdir
Malheiro, Angela
Cordova, Caio M.M.
Bella Cruz, Alexandre
author_facet Silveira, Alessandro C.O.
Claudino, Vanessa D.
Yunes, Rosendo Augusto
Cechinel Filho, Valdir
Malheiro, Angela
Cordova, Caio M.M.
Bella Cruz, Alexandre
author_sort Silveira, Alessandro C.O.
title Antibacterial activity and toxicity of drimys brasiliensis
title_short Antibacterial activity and toxicity of drimys brasiliensis
title_full Antibacterial activity and toxicity of drimys brasiliensis
title_fullStr Antibacterial activity and toxicity of drimys brasiliensis
title_full_unstemmed Antibacterial activity and toxicity of drimys brasiliensis
title_sort antibacterial activity and toxicity of drimys brasiliensis
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25733
http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_1.pdf
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bdutipo_str Repositorios
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