Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach

The objective of this study was to employ convolution approach for the calculation of blood drug levels for various release types (1:1, 1:1.5, and 1:2, drug:polymer) of metoprolol tartrate microparticulate formulations from in vitro drug dissolution profiles. Using USP 2007 dissolution apparatus II,...

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Detalles Bibliográficos
Autores principales: Murtaza, Ghulam, Khaled, Abdulhakim A.A., Pervaiz, Khalid, Farzana, Kalsoom
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Convolution
Dissolution
Pharmacokinetics
Metoprolol
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25728
http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_2_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25728
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Convolution
Dissolution
Pharmacokinetics
Metoprolol
spellingShingle Farmacia
Convolution
Dissolution
Pharmacokinetics
Metoprolol
Murtaza, Ghulam
Khaled, Abdulhakim A.A.
Pervaiz, Khalid
Farzana, Kalsoom
Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
topic_facet Farmacia
Convolution
Dissolution
Pharmacokinetics
Metoprolol
description The objective of this study was to employ convolution approach for the calculation of blood drug levels for various release types (1:1, 1:1.5, and 1:2, drug:polymer) of metoprolol tartrate microparticulate formulations from in vitro drug dissolution profiles. Using USP 2007 dissolution apparatus II, dissolution testing was carried out by employing sequential pH change method with and without 0.5 % soudium lauryl sulphate, surfactant. The values of derived pharmacokinetic parameters like Cmax (Maximum blood drug concentration), Tmax (Time needed to reach maximum blood drug concentration), and AUC (area under blood drug concentration curve) from the predicted drug concentration in blood were amazingly comparable to that calculated from the corresponding human in vivo data as stated in literature. As per conclusion, convolution approach is a useful analytical tool for computing drug concentration in blood as well as for evaluating product quality.
format Articulo
Comunicacion
author Murtaza, Ghulam
Khaled, Abdulhakim A.A.
Pervaiz, Khalid
Farzana, Kalsoom
author_facet Murtaza, Ghulam
Khaled, Abdulhakim A.A.
Pervaiz, Khalid
Farzana, Kalsoom
author_sort Murtaza, Ghulam
title Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
title_short Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
title_full Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
title_fullStr Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
title_full_unstemmed Metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
title_sort metoprolol-eudragit microcapsules: pharmacokinetic study using convolution approach
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25728
http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_2_3.pdf
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AT farzanakalsoom metoprololeudragitmicrocapsulespharmacokineticstudyusingconvolutionapproach
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