In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers

Spacer devices are used to optimize airway aerosol deposition from pressurized metered-dose inhalers (pMDI). The in vitro performance of the combination fluticasone/salmeterol pMDI alone and connected to 3 different valved holding chambers (VHC) was compared by measuring impactor entry port (“throat...

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Autores principales: Gonçalves, Talita M., Rizzo, José Â., Dubus, Jean-Christophe, Nicolay, Alain, Santana, Davi P., Souza, Pedro H. N. de, Figueiroa, José N., Andrieu, Veronique
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Aerosol
Distribution Particle size
Fine particle dose
Fluticasone and Salmeterol
Valved holding chamber
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/25722
http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_13.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-25722
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Aerosol
Distribution Particle size
Fine particle dose
Fluticasone and Salmeterol
Valved holding chamber
spellingShingle Farmacia
Aerosol
Distribution Particle size
Fine particle dose
Fluticasone and Salmeterol
Valved holding chamber
Gonçalves, Talita M.
Rizzo, José Â.
Dubus, Jean-Christophe
Nicolay, Alain
Santana, Davi P.
Souza, Pedro H. N. de
Figueiroa, José N.
Andrieu, Veronique
In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
topic_facet Farmacia
Aerosol
Distribution Particle size
Fine particle dose
Fluticasone and Salmeterol
Valved holding chamber
description Spacer devices are used to optimize airway aerosol deposition from pressurized metered-dose inhalers (pMDI). The in vitro performance of the combination fluticasone/salmeterol pMDI alone and connected to 3 different valved holding chambers (VHC) was compared by measuring impactor entry port (“throat”) deposition and fine particle dose (FPD) of each medication. Salmeterol (SX) and Fluticasone (FP) throat deposition was reduced over 90 % by all VHC compared to pMDI alone (p < 0,001). The FPD obtained from pMDI alone and connected to VHCs Vortex®, AeroChamber Plus® and Able Spacer® for Salmeterol (25 μg nominal dose) were 12.2 ± 0.7, 12.5 ± 0.5, 11.6 ± 0.8, and 7.9 ± 0.9 μg, respectively. For Fluticasone (125 μg nominal dose) the FPD were 42.5 ± 2.6, 36.3 ± 3.1, 39.8 ± 2.4, and 22.8 ± 3.5 μg, respectively. There were no statistical differences in FPD between devices, except for AbleSpacer® that delivered a lower FPD for both drugs (p < 0.001).
format Articulo
Articulo
author Gonçalves, Talita M.
Rizzo, José Â.
Dubus, Jean-Christophe
Nicolay, Alain
Santana, Davi P.
Souza, Pedro H. N. de
Figueiroa, José N.
Andrieu, Veronique
author_facet Gonçalves, Talita M.
Rizzo, José Â.
Dubus, Jean-Christophe
Nicolay, Alain
Santana, Davi P.
Souza, Pedro H. N. de
Figueiroa, José N.
Andrieu, Veronique
author_sort Gonçalves, Talita M.
title In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
title_short In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
title_full In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
title_fullStr In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
title_full_unstemmed In vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
title_sort in vitro performance of fluticasone/salmeterol pressurized metered dose inhaler in combination with three different valved holding chambers
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/25722
http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_13.pdf
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