Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets

The present study was designed to evaluate the preparation and quality of ibuprofen and diphenhydramine hydrochloride orally disintegrating tablets. The formulation was optimized with disintegration time and taste as reference parameters by single-factor and orthogonal experiments. Then the hardness...

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Detalles Bibliográficos
Autores principales:	Luo, Y.H., Ge, Z. K., Zhao, X.Y., Chen, Q., Bourkaib, Nadia, Luo, M., Luo, L.Y., Wu, Lei, Hu, B. X.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia diphenhydramine HCl formulation orally disintegrating tablet Ibuprofeno
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/25696 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_9.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-25696
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia diphenhydramine HCl formulation orally disintegrating tablet Ibuprofeno
spellingShingle	Farmacia diphenhydramine HCl formulation orally disintegrating tablet Ibuprofeno Luo, Y.H. Ge, Z. K. Zhao, X.Y. Chen, Q. Bourkaib, Nadia Luo, M. Luo, L.Y. Wu, Lei Hu, B. X. Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets
topic_facet	Farmacia diphenhydramine HCl formulation orally disintegrating tablet Ibuprofeno
description	The present study was designed to evaluate the preparation and quality of ibuprofen and diphenhydramine hydrochloride orally disintegrating tablets. The formulation was optimized with disintegration time and taste as reference parameters by single-factor and orthogonal experiments. Then the hardness, disintegrating time and dissolution were examined. The best prescription was found to contain: ibuprofen 200 mg, diphenhydramine HCl 25 mg, citric acid 30 mg, microcrystalline cellulose 115 mg, mannitol 48.5 mg, polyvinylpolypyrrolidone 40 mg, sodium lauryl sulphate 10 mg, magnesium Stearate 3.5 mg, gum arabic 1.5 mg, aspartame 15 mg, steviosin 1.5 mg, and sodium bicarbonate 10 mg. The orally disintegrating tablets were congruent and smooth with pleasant taste in mouth. The disintegration time was less than 60 s, and more than 80 % of ibuprofen and diphenhydramine HCl were dissolved within 10 min. Consequently, the formulation design is reasonable and the process of preparation is feasible.
format	Articulo Articulo
author	Luo, Y.H. Ge, Z. K. Zhao, X.Y. Chen, Q. Bourkaib, Nadia Luo, M. Luo, L.Y. Wu, Lei Hu, B. X.
author_facet	Luo, Y.H. Ge, Z. K. Zhao, X.Y. Chen, Q. Bourkaib, Nadia Luo, M. Luo, L.Y. Wu, Lei Hu, B. X.
author_sort	Luo, Y.H.
title	Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets
title_short	Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets
title_full	Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets
title_fullStr	Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets
title_full_unstemmed	Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets
title_sort	preparation and quality evaluation of ibuprofen and piphenhydramine hydrochloride orally disintegrating tablets
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/25696 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_9.pdf
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Preparation and quality evaluation of Ibuprofen and Piphenhydramine hydrochloride orally disintegrating tablets

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