Pharmacokinetics, tissue distribution and excretion of Vitexin in mice
Pharmacokinetics, tissue distribution and excretion of vitexin (VIT) were studied after intravenous and oral administration to mice at dose of 10 mg/kg and 30 mg/kg, respectively. A sensitive and specific HPLC method with internal standard was developed and validated for the pharmacokinetic studies...
Guardado en:
| Autores principales: | , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25695 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_8.pdf |
| Aporte de: |
| id |
I19-R120-10915-25695 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacocinética Distribución Tisular Cromatografía Líquida de Alta Presión excretion Vitexin |
| spellingShingle |
Farmacia Farmacocinética Distribución Tisular Cromatografía Líquida de Alta Presión excretion Vitexin Wang, Yun-jiao Qu, Gong-lin Zhang, Wen-jie Xue, He-fei Chen, Ying-hui Yin, Jing-jing Lu, Dong-rui Ying, Xi-xiang Pharmacokinetics, tissue distribution and excretion of Vitexin in mice |
| topic_facet |
Farmacia Farmacocinética Distribución Tisular Cromatografía Líquida de Alta Presión excretion Vitexin |
| description |
Pharmacokinetics, tissue distribution and excretion of vitexin (VIT) were studied after intravenous and oral administration to mice at dose of 10 mg/kg and 30 mg/kg, respectively. A sensitive and specific HPLC method with internal standard was developed and validated for the pharmacokinetic studies of VIT. The results showed that VIT was rapidly and widespreadly distributed throughout the whole body after administration and the oral bioavailability of VIT was 3.91 %. The highest VIT level after intravenous dose was obtained in gallbladder, followed by lung, liver and kidney. While, the highest VIT level after oral dose was observed in gallbladder, followed by intestine, stomach, and spleen. The total cumulative excretion percentage of VIT in 24 h after intravenous and oral administration are 31.83 ± 3.85 % (22.72 ± 2.23 % in urinary excretion; 9.11 ± 1.69 % in fecal excretion) and 10.77 ± 2.34 % (2.92 ±1.05 % in urinary excretion; 7.85 ± 1.45 % in fecal excretion), respectively. |
| format |
Articulo Articulo |
| author |
Wang, Yun-jiao Qu, Gong-lin Zhang, Wen-jie Xue, He-fei Chen, Ying-hui Yin, Jing-jing Lu, Dong-rui Ying, Xi-xiang |
| author_facet |
Wang, Yun-jiao Qu, Gong-lin Zhang, Wen-jie Xue, He-fei Chen, Ying-hui Yin, Jing-jing Lu, Dong-rui Ying, Xi-xiang |
| author_sort |
Wang, Yun-jiao |
| title |
Pharmacokinetics, tissue distribution and excretion of Vitexin in mice |
| title_short |
Pharmacokinetics, tissue distribution and excretion of Vitexin in mice |
| title_full |
Pharmacokinetics, tissue distribution and excretion of Vitexin in mice |
| title_fullStr |
Pharmacokinetics, tissue distribution and excretion of Vitexin in mice |
| title_full_unstemmed |
Pharmacokinetics, tissue distribution and excretion of Vitexin in mice |
| title_sort |
pharmacokinetics, tissue distribution and excretion of vitexin in mice |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/25695 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_8.pdf |
| work_keys_str_mv |
AT wangyunjiao pharmacokineticstissuedistributionandexcretionofvitexininmice AT qugonglin pharmacokineticstissuedistributionandexcretionofvitexininmice AT zhangwenjie pharmacokineticstissuedistributionandexcretionofvitexininmice AT xuehefei pharmacokineticstissuedistributionandexcretionofvitexininmice AT chenyinghui pharmacokineticstissuedistributionandexcretionofvitexininmice AT yinjingjing pharmacokineticstissuedistributionandexcretionofvitexininmice AT ludongrui pharmacokineticstissuedistributionandexcretionofvitexininmice AT yingxixiang pharmacokineticstissuedistributionandexcretionofvitexininmice |
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Repositorios |
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1764820466778767360 |