Pharmacological evaluation of two liposomal doxorubicin formulations
Two liposomal formulations of doxorubicin (Caelyx® and Doxopeg®) were evaluated for phospholipid content, doxorubicin concentration, liposomal size, zeta potential, osmolarity, phospholipid peroxidation, in vitro release of the drug, pharmacokinetic profile, and cytotoxicity in cancer cell cultures....
Guardado en:
| Autores principales: | , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25650 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_7.pdf |
| Aporte de: |
| id |
I19-R120-10915-25650 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Doxorrubicina Liposomas |
| spellingShingle |
Farmacia Doxorrubicina Liposomas Medina, Luis A. Martínez Acevedo, Lizbeth Juárez Osornio, Carlos García López, Patricia Pérez Rojas, Jazmín Jurado, Rafael Vázquez Becerra, Héctor Pharmacological evaluation of two liposomal doxorubicin formulations |
| topic_facet |
Farmacia Doxorrubicina Liposomas |
| description |
Two liposomal formulations of doxorubicin (Caelyx® and Doxopeg®) were evaluated for phospholipid content, doxorubicin concentration, liposomal size, zeta potential, osmolarity, phospholipid peroxidation, in vitro release of the drug, pharmacokinetic profile, and cytotoxicity in cancer cell cultures.
Phospholipid concentration was not statistically different between formulations. Doxorubicin concentration was in the range of 2.0 mg/mL. Size and zeta potential were in the order of 80 nm and -37 mV, respectively. Osmolarity and peroxidation in both formulations was similar and the in vitro drug release assay indicated minimal release (2 %) of the doxorubicin content after 48 h. Pharmacokinetics parameters in both formulations were very similar and no statistical difference was observed between them; the effect on the growth inhibition in cell lines was also not different. Caelyx® and Doxopeg® are similar in terms of its composition, physical parameters, stability, pharmacokinetics and growth inhibition in cancer cell lines. |
| format |
Articulo Articulo |
| author |
Medina, Luis A. Martínez Acevedo, Lizbeth Juárez Osornio, Carlos García López, Patricia Pérez Rojas, Jazmín Jurado, Rafael Vázquez Becerra, Héctor |
| author_facet |
Medina, Luis A. Martínez Acevedo, Lizbeth Juárez Osornio, Carlos García López, Patricia Pérez Rojas, Jazmín Jurado, Rafael Vázquez Becerra, Héctor |
| author_sort |
Medina, Luis A. |
| title |
Pharmacological evaluation of two liposomal doxorubicin formulations |
| title_short |
Pharmacological evaluation of two liposomal doxorubicin formulations |
| title_full |
Pharmacological evaluation of two liposomal doxorubicin formulations |
| title_fullStr |
Pharmacological evaluation of two liposomal doxorubicin formulations |
| title_full_unstemmed |
Pharmacological evaluation of two liposomal doxorubicin formulations |
| title_sort |
pharmacological evaluation of two liposomal doxorubicin formulations |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/25650 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_7.pdf |
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Repositorios |
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