Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis

This study focused on developing in situ gel formulations of miconazole nitrate with poloxamer 188 and 407 for treatment of mucosal candidiasis. In situ gel formulations were prepared and gelation temperature, rheological, mechanical and mucoadhesive properties, syringeability and release profiles w...

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Detalles Bibliográficos
Autores principales:	Karavana, Sinem Y., Senyi'it, Zeynep A., Hilmioglu Polat, Süleyha, Metin, Dilek Y., Zekioglu, Osman, Baloglu, Esra
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Candidiasis Miconazol Poloxámero
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/25644 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-25644
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Candidiasis Miconazol Poloxámero
spellingShingle	Farmacia Candidiasis Miconazol Poloxámero Karavana, Sinem Y. Senyi'it, Zeynep A. Hilmioglu Polat, Süleyha Metin, Dilek Y. Zekioglu, Osman Baloglu, Esra Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
topic_facet	Farmacia Candidiasis Miconazol Poloxámero
description	This study focused on developing in situ gel formulations of miconazole nitrate with poloxamer 188 and 407 for treatment of mucosal candidiasis. In situ gel formulations were prepared and gelation temperature, rheological, mechanical and mucoadhesive properties, syringeability and release profiles were evaluated. Based on their suitable gelation temperature properties, formulations containing the poloxamer (Plx) 407 and 188 in ratios of 15:15 (F1), 15:20 (F2) and 20:10 (F3) were chosen for further studies. F3 exhibited typical gel-type mechanical spectra at 37 °C whereas F1 and F2 behaved like weakly cross-linked gels. Texture profile analysis demonstrated that F3 showed the highest cohesiveness, adhesiveness, hardness and compressibility. According to the these results, F3 was chosen for in vivo studies and it was shown that it is effective for the treatment of the vaginal candidiasis. Histopathologic evaluation also supported the effectiveness of the formulation. As a result, in situ gel formulations prepared with Plx 407 and 188 mixture of miconazole nitrate proved to be a promising alternative dosage form for treatment of mucosal candidiasis
format	Articulo Articulo
author	Karavana, Sinem Y. Senyi'it, Zeynep A. Hilmioglu Polat, Süleyha Metin, Dilek Y. Zekioglu, Osman Baloglu, Esra
author_facet	Karavana, Sinem Y. Senyi'it, Zeynep A. Hilmioglu Polat, Süleyha Metin, Dilek Y. Zekioglu, Osman Baloglu, Esra
author_sort	Karavana, Sinem Y.
title	Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_short	Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_full	Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_fullStr	Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_full_unstemmed	Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_sort	mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/25644 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_5.pdf
work_keys_str_mv	AT karavanasinemy mucoadhesiveinsitugelformulationsofmiconazolenitrateforthetreatmentofmucosalcandidiasis AT senyiitzeynepa mucoadhesiveinsitugelformulationsofmiconazolenitrateforthetreatmentofmucosalcandidiasis AT hilmioglupolatsuleyha mucoadhesiveinsitugelformulationsofmiconazolenitrateforthetreatmentofmucosalcandidiasis AT metindileky mucoadhesiveinsitugelformulationsofmiconazolenitrateforthetreatmentofmucosalcandidiasis AT zekiogluosman mucoadhesiveinsitugelformulationsofmiconazolenitrateforthetreatmentofmucosalcandidiasis AT balogluesra mucoadhesiveinsitugelformulationsofmiconazolenitrateforthetreatmentofmucosalcandidiasis
bdutipo_str	Repositorios
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Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis

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