Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels
This study involves an investigation of the effects of crosslinking of gellan gum (GG) with Ca<sup>++</sup> or Zn++ on the physical properties of GG gels. GG gels crosslinked with different concentrations of Ca<sup>++</sup> or Zn<sup>++</sup> were prepared and par...
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25642 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_4.pdf |
| Aporte de: |
| id |
I19-R120-10915-25642 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia floating beads gellan gum penetration thickness entrapment efficiency water holding capacity |
| spellingShingle |
Farmacia floating beads gellan gum penetration thickness entrapment efficiency water holding capacity Verma, Anurag Pandit, Jayant K. Wahi, Arun K. Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels |
| topic_facet |
Farmacia floating beads gellan gum penetration thickness entrapment efficiency water holding capacity |
| description |
This study involves an investigation of the effects of crosslinking of gellan gum (GG) with Ca<sup>++</sup> or Zn++ on the physical properties of GG gels. GG gels crosslinked with different concentrations of Ca<sup>++</sup> or Zn<sup>++</sup> were prepared and parameters such as % water holding capacity and penetration thickness were investigated as measures of the extent of interaction of Ca<sup>++</sup> or Zn<sup>++</sup> with GG molecules. Data generated from the above studies revealed that Zn<sup>++</sup> interacted with the GG molecules to a greater extent than Ca++ . In order to further strengthen our finding, we have prepared Zn<sup>++</sup> crosslinked and Ca<sup>++</sup> crosslinked floating GG beads respectively by ionotropic gelation in the presence of a gas-generating agent (NaHCO3 ) and compared their physico-chemical properties such as density, drug entrapment efficiency and release in 0.1 M HCl (pH 1.2) using metronidazole (MTZ) as a model drug. Experimental data suggested that Zn<sup>++</sup> crosslinked floating GG beads were denser and less buoyant than Ca<sup>++</sup> crosslinked floating beads but capable of significantly (p < 0.05) improving MTZ entrapment efficiency and sustaining the MTZ release in 0.1 M HCl (pH 1.2) compared to Ca++ crosslinked floating beads. The difference in observed behavior may be attributed to differences in specificity, soft and hard character, enthalpies of hydration and ionization potentials of Ca<sup>++</sup> and Zn<sup>++</sup> . |
| format |
Articulo Articulo |
| author |
Verma, Anurag Pandit, Jayant K. Wahi, Arun K. |
| author_facet |
Verma, Anurag Pandit, Jayant K. Wahi, Arun K. |
| author_sort |
Verma, Anurag |
| title |
Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels |
| title_short |
Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels |
| title_full |
Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels |
| title_fullStr |
Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels |
| title_full_unstemmed |
Effect of crosslinking with Ca<sup>++</sup> and Zn<sup>++</sup> in the formation of gellan gum gels |
| title_sort |
effect of crosslinking with ca<sup>++</sup> and zn<sup>++</sup> in the formation of gellan gum gels |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/25642 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_4.pdf |
| work_keys_str_mv |
AT vermaanurag effectofcrosslinkingwithcasupsupandznsupsupintheformationofgellangumgels AT panditjayantk effectofcrosslinkingwithcasupsupandznsupsupintheformationofgellangumgels AT wahiarunk effectofcrosslinkingwithcasupsupandznsupsupintheformationofgellangumgels |
| bdutipo_str |
Repositorios |
| _version_ |
1764820466630918144 |