Antihypertensive therapeutic potential of citronellal
Cardiovascular effects induced by citronellal in rats were investigated in this study. In LNAME hypertensive rats, the oral acute administration of citronellal (200 mg/kg) was able to significantly reduce the blood pressure. In normotensive rats, citronellal (5-40 mg/kg, i.v.) induced hypotension, w...
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| Autores principales: | , , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/20238 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_7.pdf |
| Aporte de: |
| Sumario: | Cardiovascular effects induced by citronellal in rats were investigated in this study. In LNAME hypertensive rats, the oral acute administration of citronellal (200 mg/kg) was able to significantly reduce the blood pressure. In normotensive rats, citronellal (5-40 mg/kg, i.v.) induced hypotension, which was not affected by pre-treatment with atropine, hexamethonium, L-NAME or indomethacin, and bradycardia, which was abolished by atropine and hexamethonium, but not by L-NAME or indomethacin. ECG records revealed that citronellal induced sinoatrial block, which was abolished after atropine. In intact rings of rat mesenteric artery pre-contracted with phenylephrine (10 μM), citronellal (10 –6 to 10 –1 M) was able to induce relaxations (Emax = 106.3 ± 9.4 %) that were not affected by endothelium removal or after pre-contraction with KCl 80 mM. In conclusion, these results demonstrate that citronellal reduces blood pressure. Furthermore, citronellal induces endothelium-independent vasorelaxation in rat artery that appears to involve inhibition of Ca2+ influx. |
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