Antihypertensive therapeutic potential of citronellal
Cardiovascular effects induced by citronellal in rats were investigated in this study. In LNAME hypertensive rats, the oral acute administration of citronellal (200 mg/kg) was able to significantly reduce the blood pressure. In normotensive rats, citronellal (5-40 mg/kg, i.v.) induced hypotension, w...
| Autores principales: | , , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/20238 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_7.pdf |
| Aporte de: |
| id |
I19-R120-10915-20238 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia terapéutica Bradicardia Bradycardia Citronellal Hypotension Vasorelaxant effect |
| spellingShingle |
Farmacia terapéutica Bradicardia Bradycardia Citronellal Hypotension Vasorelaxant effect Andrade, Fernando C. Mota, Marcelo M. Barreto, André S. Sousa, Damião P. Quintans Júnior, Lucindo José Santos, Márcio R.V. Antihypertensive therapeutic potential of citronellal |
| topic_facet |
Farmacia terapéutica Bradicardia Bradycardia Citronellal Hypotension Vasorelaxant effect |
| description |
Cardiovascular effects induced by citronellal in rats were investigated in this study. In LNAME hypertensive rats, the oral acute administration of citronellal (200 mg/kg) was able to significantly reduce the blood pressure. In normotensive rats, citronellal (5-40 mg/kg, i.v.) induced hypotension, which was not affected by pre-treatment with atropine, hexamethonium, L-NAME or indomethacin, and bradycardia, which was abolished by atropine and hexamethonium, but not by L-NAME or indomethacin. ECG records revealed that citronellal induced sinoatrial block, which was abolished after atropine. In intact rings of rat mesenteric artery pre-contracted with phenylephrine (10 μM), citronellal (10 –6 to 10 –1 M) was able to induce relaxations (Emax = 106.3 ± 9.4 %) that were not affected by endothelium removal or after pre-contraction with KCl 80 mM. In conclusion, these results demonstrate that citronellal reduces blood pressure. Furthermore, citronellal induces endothelium-independent vasorelaxation in rat artery that appears to involve inhibition of Ca2+ influx. |
| format |
Articulo Comunicacion |
| author |
Andrade, Fernando C. Mota, Marcelo M. Barreto, André S. Sousa, Damião P. Quintans Júnior, Lucindo José Santos, Márcio R.V. |
| author_facet |
Andrade, Fernando C. Mota, Marcelo M. Barreto, André S. Sousa, Damião P. Quintans Júnior, Lucindo José Santos, Márcio R.V. |
| author_sort |
Andrade, Fernando C. |
| title |
Antihypertensive therapeutic potential of citronellal |
| title_short |
Antihypertensive therapeutic potential of citronellal |
| title_full |
Antihypertensive therapeutic potential of citronellal |
| title_fullStr |
Antihypertensive therapeutic potential of citronellal |
| title_full_unstemmed |
Antihypertensive therapeutic potential of citronellal |
| title_sort |
antihypertensive therapeutic potential of citronellal |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/20238 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_7.pdf |
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Repositorios |
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