Validation of microbiological assay for determination of cefuroxime in injectable preparations

The validation of a microbiological assay, applying agar diffusion method for determination of the active of cefuroxime in power for injection, is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, cefuroxime was measured in concentrations ranging from 30.0 to 120.0 μg/m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Vieira, Daniela C.M., Ricarte, Patrícia C., Salgado, Hérida R.N.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Cefuroxime
Cephalosporins
Microbiological assay
Quality control
Validation
Cefuroxima
Cefalosporinas
Control de Calidad
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20229
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20229
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Cefuroxime
Cephalosporins
Microbiological assay
Quality control
Validation
Cefuroxima
Cefalosporinas
Control de Calidad
spellingShingle Farmacia
Cefuroxime
Cephalosporins
Microbiological assay
Quality control
Validation
Cefuroxima
Cefalosporinas
Control de Calidad
Vieira, Daniela C.M.
Ricarte, Patrícia C.
Salgado, Hérida R.N.
Validation of microbiological assay for determination of cefuroxime in injectable preparations
topic_facet Farmacia
Cefuroxime
Cephalosporins
Microbiological assay
Quality control
Validation
Cefuroxima
Cefalosporinas
Control de Calidad
description The validation of a microbiological assay, applying agar diffusion method for determination of the active of cefuroxime in power for injection, is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, cefuroxime was measured in concentrations ranging from 30.0 to 120.0 μg/mL. The method validation showed that it is linear (r = 0.9999), precise (relative standard deviation = 0.37 %) and accurate (it measured the added quantities). Microbiological assay is satisfactory for quantitation of cefuroxime in powder for injection and the validity of the proposed bioassay, which is a simple and a useful alternative methodology for cefuroxime determination in routine quality control.
format Articulo
Comunicacion
author Vieira, Daniela C.M.
Ricarte, Patrícia C.
Salgado, Hérida R.N.
author_facet Vieira, Daniela C.M.
Ricarte, Patrícia C.
Salgado, Hérida R.N.
author_sort Vieira, Daniela C.M.
title Validation of microbiological assay for determination of cefuroxime in injectable preparations
title_short Validation of microbiological assay for determination of cefuroxime in injectable preparations
title_full Validation of microbiological assay for determination of cefuroxime in injectable preparations
title_fullStr Validation of microbiological assay for determination of cefuroxime in injectable preparations
title_full_unstemmed Validation of microbiological assay for determination of cefuroxime in injectable preparations
title_sort validation of microbiological assay for determination of cefuroxime in injectable preparations
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20229
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_2.pdf
work_keys_str_mv AT vieiradanielacm validationofmicrobiologicalassayfordeterminationofcefuroximeininjectablepreparations
AT ricartepatriciac validationofmicrobiologicalassayfordeterminationofcefuroximeininjectablepreparations
AT salgadoheridarn validationofmicrobiologicalassayfordeterminationofcefuroximeininjectablepreparations
bdutipo_str Repositorios
_version_ 1764820465500553220

Ejemplares similares