Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions

The aim of this work was to investigate the potential of Glucam® P-20 as a skin penetration enhancer for diclofenac sodium microemulsions across excised newborn pig skin. Glucam® P-20 (GP-20) or PPG-20-methyl glucose ether is generally used as a humectant, emollient and fragrance fixative. The w/o m...

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Autores principales: Songkro, Sarunyoo, Tanmanee, Niwan, Maneenuan, Duangkhae, Chuchome, Thitima, Lo, Nai-Lun, Boonme, Prapaporn
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Diclofenac sodium
Microemulsions
Glucam® P-20
Skin penetration enhance
In Vitro
Diclofenaco
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20226
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_14.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20226
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Diclofenac sodium
Microemulsions
Glucam® P-20
Skin penetration enhance
In Vitro
Diclofenaco
spellingShingle Farmacia
Diclofenac sodium
Microemulsions
Glucam® P-20
Skin penetration enhance
In Vitro
Diclofenaco
Songkro, Sarunyoo
Tanmanee, Niwan
Maneenuan, Duangkhae
Chuchome, Thitima
Lo, Nai-Lun
Boonme, Prapaporn
Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions
topic_facet Farmacia
Diclofenac sodium
Microemulsions
Glucam® P-20
Skin penetration enhance
In Vitro
Diclofenaco
description The aim of this work was to investigate the potential of Glucam® P-20 as a skin penetration enhancer for diclofenac sodium microemulsions across excised newborn pig skin. Glucam® P-20 (GP-20) or PPG-20-methyl glucose ether is generally used as a humectant, emollient and fragrance fixative. The w/o microemulsions composed of Tween 80, Eutanol G and water were formulated. The concentration of diclofenac sodium was 1 % w/w while the amounts of GP-20 were varied from 0-20 % w/w, ME-1 (0 %), ME-2 (5 %), ME-3 (10 %) and ME-4 (20 %). All microemulsions were transparent with Newtonian flow behaviour. The mean droplet sizes of the microemulsions were about 200 nm. The FTIR spectra of the microemulsions containing GP-20 were not markedly different from those of the microemulsion without GP- 20, ME-1. The in vitro release and skin permeation studies of diclofenac sodium loaded microemulsions were investigated using modified Franz diffusion cell. For the in vitro release across synthetic membrane, the rank order of the release rate was ME-4 > ME-3 > ME-2 > ME-1. For the in vitro skin permeation experiments, GP-20 at 10 % and 20 % could markedly enhance the percutaneous absorption of the drug. The optimum concentration of GP-20 was 10 %. GP-20 is proposed as a potential skin penetration enhancer for percutaneous absorption of diclofenac sodium.
format Articulo
Articulo
author Songkro, Sarunyoo
Tanmanee, Niwan
Maneenuan, Duangkhae
Chuchome, Thitima
Lo, Nai-Lun
Boonme, Prapaporn
author_facet Songkro, Sarunyoo
Tanmanee, Niwan
Maneenuan, Duangkhae
Chuchome, Thitima
Lo, Nai-Lun
Boonme, Prapaporn
author_sort Songkro, Sarunyoo
title Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions
title_short Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions
title_full Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions
title_fullStr Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions
title_full_unstemmed Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions
title_sort investigation of enhancing effect of glucam® p-20 on the in vitro skin permeation of diclofenac sodium microemulsions
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20226
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_14.pdf
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