Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach

In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of the analgesic drug indomethacin in propylene glycol + water mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order four (overall dev...

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Detalles Bibliográficos
Autores principales: Holguín, Andrés R., Delgado, Daniel R., Martínez, Fleming
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Indometacina
Solubilidad
Glicoles de Propileno
Agua
Binary mixtures
Extended Hildebrand solubility approach
Indomethacin
Solubility parameter
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20224
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20224
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Indometacina
Solubilidad
Glicoles de Propileno
Agua
Binary mixtures
Extended Hildebrand solubility approach
Indomethacin
Solubility parameter
spellingShingle Farmacia
Indometacina
Solubilidad
Glicoles de Propileno
Agua
Binary mixtures
Extended Hildebrand solubility approach
Indomethacin
Solubility parameter
Holguín, Andrés R.
Delgado, Daniel R.
Martínez, Fleming
Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
topic_facet Farmacia
Indometacina
Solubilidad
Glicoles de Propileno
Agua
Binary mixtures
Extended Hildebrand solubility approach
Indomethacin
Solubility parameter
description In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of the analgesic drug indomethacin in propylene glycol + water mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order four (overall deviation lower than 2.2 %), when the W interaction parameter is related to the solubility parameter of the mixtures. Nevertheless, the deviations obtained in the estimated solubility with respect to experimental solubility were similar to those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures’ solubility parameters.
format Articulo
Articulo
author Holguín, Andrés R.
Delgado, Daniel R.
Martínez, Fleming
author_facet Holguín, Andrés R.
Delgado, Daniel R.
Martínez, Fleming
author_sort Holguín, Andrés R.
title Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
title_short Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
title_full Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
title_fullStr Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
title_full_unstemmed Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
title_sort indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20224
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_12.pdf
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