Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption

The aim of the present study was to evaluate intrathecal morphine outcome on postoperative pain and apply pharmacokinetic/pharmacodynamic model to justify morphine consumption, plasma concentration and pain intensity during coronary artery bypass grafting surgery. Thirty six patients were prospectiv...

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Autores principales:	Santos, Veronica C.J., Sanches Giraud, Cristina, Lanchote, Vera L., Santos, Luciana M., Carmona, María J. C., Santos, Silvia R. C. J.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Analgesia Intrathecal morphine Pharmacokinetic/pharmacodynamic modeling Postoperative patient-controlled analgesia device Morfina Farmacocinética
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20219 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_7.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-20219
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Analgesia Intrathecal morphine Pharmacokinetic/pharmacodynamic modeling Postoperative patient-controlled analgesia device Morfina Farmacocinética
spellingShingle	Farmacia Analgesia Intrathecal morphine Pharmacokinetic/pharmacodynamic modeling Postoperative patient-controlled analgesia device Morfina Farmacocinética Santos, Veronica C.J. Sanches Giraud, Cristina Lanchote, Vera L. Santos, Luciana M. Carmona, María J. C. Santos, Silvia R. C. J. Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption
topic_facet	Farmacia Analgesia Intrathecal morphine Pharmacokinetic/pharmacodynamic modeling Postoperative patient-controlled analgesia device Morfina Farmacocinética
description	The aim of the present study was to evaluate intrathecal morphine outcome on postoperative pain and apply pharmacokinetic/pharmacodynamic model to justify morphine consumption, plasma concentration and pain intensity during coronary artery bypass grafting surgery. Thirty six patients were prospectively randomized for general anesthesia and allocated in the control or morphine (400 μg intrathecal) group. At postoperative period, all patients received a loading dose of morphine (1 mg bolus), and then patient-controlled analgesia device was installed and delivered until 36 h. Blood samples was collected from venous catheter, morphine plasma concentrations were determined by liquid chromatography and pain intensity evaluated by visual analogue scale. Drug dose requirements and pain intensity at rest were different between groups. No kinetic parameters difference was obtained. Maximum effect model and hysteresis curve were proposed to correlate drug plasma concentration versus time, drug consumption and pain intensity. Intrathecal morphine reduces at rest morphine consumption and pain intensity postoperatively; the best fit pharmacokinetic/pharmacodynamic models were maximum effect and hysteresis curve
format	Articulo Articulo
author	Santos, Veronica C.J. Sanches Giraud, Cristina Lanchote, Vera L. Santos, Luciana M. Carmona, María J. C. Santos, Silvia R. C. J.
author_facet	Santos, Veronica C.J. Sanches Giraud, Cristina Lanchote, Vera L. Santos, Luciana M. Carmona, María J. C. Santos, Silvia R. C. J.
author_sort	Santos, Veronica C.J.
title	Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption
title_short	Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption
title_full	Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption
title_fullStr	Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption
title_full_unstemmed	Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption
title_sort	pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : intrathecal morphine significantly reduces drug consumption
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20219 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_7.pdf
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Pk/pd of morphine for postoperative analgesia after coronary artery bypass grafting : Intrathecal morphine significantly reduces drug consumption

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