Formulation and in-vitro evaluation of topically applied curcumin hydrogel

The study aims to investigate a transdermal hydrogel formulation containing curcumin, which would attenuate the low bioavailability associated with oral administration of the drug. Carboxy polymethylene was used to develop topical hydrogel formulations of curcumin with different concentrations of pe...

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Detalles Bibliográficos
Autores principales:	Nawaz, Asif, Khan, Gul M., Akhlaq, Muhammad, Zeb, Alam, Hussain, Abid, Dayo, Abdullah
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia aceite de oliva In Vitro Hidrogel Curcumina Polisorbatos Carboxy polymethylene Curcumin hydrogel Olive oil Penetration enhancer Polysorbate 80 (tween 80)
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20217 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia aceite de oliva In Vitro Hidrogel Curcumina Polisorbatos Carboxy polymethylene Curcumin hydrogel Olive oil Penetration enhancer Polysorbate 80 (tween 80)
spellingShingle	Farmacia aceite de oliva In Vitro Hidrogel Curcumina Polisorbatos Carboxy polymethylene Curcumin hydrogel Olive oil Penetration enhancer Polysorbate 80 (tween 80) Nawaz, Asif Khan, Gul M. Akhlaq, Muhammad Zeb, Alam Hussain, Abid Dayo, Abdullah Formulation and in-vitro evaluation of topically applied curcumin hydrogel
topic_facet	Farmacia aceite de oliva In Vitro Hidrogel Curcumina Polisorbatos Carboxy polymethylene Curcumin hydrogel Olive oil Penetration enhancer Polysorbate 80 (tween 80)
description	The study aims to investigate a transdermal hydrogel formulation containing curcumin, which would attenuate the low bioavailability associated with oral administration of the drug. Carboxy polymethylene was used to develop topical hydrogel formulations of curcumin with different concentrations of penetration enhancers. Rheological properties, drug content, skin irritation, stability and in-vitro permeation studies were conducted. Permeation experiments were performed on silicon membrane and excised abdominal rabbit skin using Franz Diffusion Cell. All the prepared hydrogel formulations containing Curcumin showed good consistency, homogeneity, spreadability and has wider prospect for topical preparation. The formulation containing Curcumin (2 % w/w gel) and olive oil (2 % w/w, as enhancer) was found to have good permeation of the drug across artificial skin as well as rabbit skin. The anti-inflammatory activity of 2 % w/w Curcumin hydrogel in the rat hind paw edema model revealed that the drug was delivered to the inflammation site at a controlled rate over a desired period of about 3 h, using carboxy polymethylene as gel forming polymer and olive oil and tween 80 as penetration enhancers.
format	Articulo Articulo
author	Nawaz, Asif Khan, Gul M. Akhlaq, Muhammad Zeb, Alam Hussain, Abid Dayo, Abdullah
author_facet	Nawaz, Asif Khan, Gul M. Akhlaq, Muhammad Zeb, Alam Hussain, Abid Dayo, Abdullah
author_sort	Nawaz, Asif
title	Formulation and in-vitro evaluation of topically applied curcumin hydrogel
title_short	Formulation and in-vitro evaluation of topically applied curcumin hydrogel
title_full	Formulation and in-vitro evaluation of topically applied curcumin hydrogel
title_fullStr	Formulation and in-vitro evaluation of topically applied curcumin hydrogel
title_full_unstemmed	Formulation and in-vitro evaluation of topically applied curcumin hydrogel
title_sort	formulation and in-vitro evaluation of topically applied curcumin hydrogel
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20217 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_5.pdf
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bdutipo_str	Repositorios
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Formulation and in-vitro evaluation of topically applied curcumin hydrogel

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