Determination of pantoprazole in rat plasma by LC–MS/MS and its application to pharmacokinetics

A highly sensitive liquid chromatographic mass spectrometric (LC-MS/MS) method for determination of pantoprazole in rat plasma using omeprazole as the internal standard (IS) was developed. Plasma samples were precipitated by acetonitrile and separated on a Zorbax SB-C18 column with gradient profile...

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Autores principales: Qiu, Xiangjun, Xu, Ren-ai, Zheng, Yuancai, Zhan, Haichao, Wang, Zhe, Hu, Lufeng
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
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Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20214
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_2.pdf
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