20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation

Drug-drug interaction (DDI) is a challenging problem for treatment of HIV-infected patients. Zidovudine (AZT), prescribed under the names Retrovir and Retrovis, is the first U.S. government-approved antiretroviral drug used for the successful treatment of HIV/AIDS infectiousness. Given that ginseng...

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Detalles Bibliográficos
Autores principales:	Xing, Jin, Che, Wen
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Herb-drug interaction Glucuronosiltransferasa Ginseng Zidovudina UDP-glucuronosyltransferases (UGTs) Interacciones de Hierba-Droga Zidovudine (AZT)
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20209 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_4.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-20209
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Herb-drug interaction Glucuronosiltransferasa Ginseng Zidovudina UDP-glucuronosyltransferases (UGTs) Interacciones de Hierba-Droga Zidovudine (AZT)
spellingShingle	Farmacia Herb-drug interaction Glucuronosiltransferasa Ginseng Zidovudina UDP-glucuronosyltransferases (UGTs) Interacciones de Hierba-Droga Zidovudine (AZT) Xing, Jin Che, Wen 20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation
topic_facet	Farmacia Herb-drug interaction Glucuronosiltransferasa Ginseng Zidovudina UDP-glucuronosyltransferases (UGTs) Interacciones de Hierba-Droga Zidovudine (AZT)
description	Drug-drug interaction (DDI) is a challenging problem for treatment of HIV-infected patients. Zidovudine (AZT), prescribed under the names Retrovir and Retrovis, is the first U.S. government-approved antiretroviral drug used for the successful treatment of HIV/AIDS infectiousness. Given that ginseng is frequently utilized in combination with AZT and AZT is mainly eliminated by UDP-glucuronosyltransferase 2B7, the aim of present study is to investigate the inhibition of UGT2B7-catalyzed AZT glucuronidation by 20(S)-protopanaxatriol type (Ppt) which is the main ginsenoside absorbed into the plasma. The results showed that ppt competitively inhibited UGT2B7-catalyzed AZT glucuronidation, and the inhibition kinetic parameter (Ki ) was determined to be 24.7 μM. Using the maximum plasma concentration of ppt (Cmax ), the alteration of area under the curve (AUC) of AZT was 6 %. All these results provide important information for understanding ginseng-AZT interaction. However, considering the complication of herbs and individuals, the in vitro-in vivo extrapolation (IV-IVE) results should be explained with more caution.
format	Articulo Comunicacion
author	Xing, Jin Che, Wen
author_facet	Xing, Jin Che, Wen
author_sort	Xing, Jin
title	20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation
title_short	20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation
title_full	20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation
title_fullStr	20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation
title_full_unstemmed	20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation
title_sort	20(s)-protopanaxatriol (ppt) exhibits inhibition towards udpglucuronosyltransferase (ugt)-catalyzed zidovudine glucuronidation
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20209 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_4.pdf
work_keys_str_mv	AT xingjin 20sprotopanaxatriolpptexhibitsinhibitiontowardsudpglucuronosyltransferaseugtcatalyzedzidovudineglucuronidation AT chewen 20sprotopanaxatriolpptexhibitsinhibitiontowardsudpglucuronosyltransferaseugtcatalyzedzidovudineglucuronidation
bdutipo_str	Repositorios
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20(S)-Protopanaxatriol (Ppt) Exhibits Inhibition Towards UDPGlucuronosyltransferase (UGT)-Catalyzed Zidovudine Glucuronidation

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