Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis

The aim of this research was to evaluate the effect of the angiotensin converting enzyme (ACE) inhibitor fosinopril on liver fibrosis in rats with high fat diet (HFD) induced nonalcoholic steatohepatitis (NASH). We found that treatment with fosinopril improved liver fibrosis. Moreover, treatment wit...

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Detalles Bibliográficos
Autores principales: Liu, Bo, Wu, Rong, Zhang, Wei, Zhang, Feng, Zhou, Huamei, Wang, Lulu, Xiao, Xiaoqiu, Zhang, Xia, Wu, Xiaoling
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Adiponectin
Angiotensin converting enzyme 2
Fosinopril
Leptin
Liver fibrosis
Non-alcoholic steatohepatitis
Fibrosis
Ratas
Leptina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20188
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20188
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Adiponectin
Angiotensin converting enzyme 2
Fosinopril
Leptin
Liver fibrosis
Non-alcoholic steatohepatitis
Fibrosis
Ratas
Leptina
spellingShingle Farmacia
Adiponectin
Angiotensin converting enzyme 2
Fosinopril
Leptin
Liver fibrosis
Non-alcoholic steatohepatitis
Fibrosis
Ratas
Leptina
Liu, Bo
Wu, Rong
Zhang, Wei
Zhang, Feng
Zhou, Huamei
Wang, Lulu
Xiao, Xiaoqiu
Zhang, Xia
Wu, Xiaoling
Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
topic_facet Farmacia
Adiponectin
Angiotensin converting enzyme 2
Fosinopril
Leptin
Liver fibrosis
Non-alcoholic steatohepatitis
Fibrosis
Ratas
Leptina
description The aim of this research was to evaluate the effect of the angiotensin converting enzyme (ACE) inhibitor fosinopril on liver fibrosis in rats with high fat diet (HFD) induced nonalcoholic steatohepatitis (NASH). We found that treatment with fosinopril improved liver fibrosis. Moreover, treatment with fosinopril decreased serum Angiotensin (Ang) II, leptin, transforming growth factor β1 and hyaluronic acid concentrations, increased serum ACE2, Ang-(1-7), and adiponectin concentrations in rats fed with HFD. In the liver, fosinopril led to decreased leptin, α-smooth muscle actin, and collagen I expression, increased ACE2 and adiponectin expression. In conclusion, Fosinopril improves liver fibrosis by upregulating ACE2/Ang-(1-7) axis activation in rats with HFD-induced NASH. Furthermore, fosinopril might regulate the progression of liver fibrosis through the downregulation of leptin and the upregulation of adiponectin.
format Articulo
Articulo
author Liu, Bo
Wu, Rong
Zhang, Wei
Zhang, Feng
Zhou, Huamei
Wang, Lulu
Xiao, Xiaoqiu
Zhang, Xia
Wu, Xiaoling
author_facet Liu, Bo
Wu, Rong
Zhang, Wei
Zhang, Feng
Zhou, Huamei
Wang, Lulu
Xiao, Xiaoqiu
Zhang, Xia
Wu, Xiaoling
author_sort Liu, Bo
title Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
title_short Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
title_full Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
title_fullStr Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
title_full_unstemmed Fosinopril improves liver fibrosis by upregulating ACE2/Angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
title_sort fosinopril improves liver fibrosis by upregulating ace2/angiotensin-(1-7) axis activation in rats with nonalcoholic steatohepatitis
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20188
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_15.pdf
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