Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time

The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are considered to be beneficial for the identification of indications and contraindica...

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Autores principales: Malkoc, Ismail, Cetin, Nihal, Altuner, Durdu, Hacimuftuoglu, Ahmet, Gursan, Nesrin, Bakan, Ebubekir, Akcay, Fatih, Suleyman, Halis
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Amlodipine
Clonidine
Methyldopa
Rat
Rilmenidine
Bioquímica
Ratas
Amlodipino
Clonidina
Metildopa
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20178
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20178
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Amlodipine
Clonidine
Methyldopa
Rat
Rilmenidine
Bioquímica
Ratas
Amlodipino
Clonidina
Metildopa
spellingShingle Farmacia
Amlodipine
Clonidine
Methyldopa
Rat
Rilmenidine
Bioquímica
Ratas
Amlodipino
Clonidina
Metildopa
Malkoc, Ismail
Cetin, Nihal
Altuner, Durdu
Hacimuftuoglu, Ahmet
Gursan, Nesrin
Bakan, Ebubekir
Akcay, Fatih
Suleyman, Halis
Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
topic_facet Farmacia
Amlodipine
Clonidine
Methyldopa
Rat
Rilmenidine
Bioquímica
Ratas
Amlodipino
Clonidina
Metildopa
description The adverse biochemical and structural effects of antihypertensive drugs over a long period (clonidine, methyldopa, rilmenidine, amlodipine, ramipril) on hepatic tissue has been examined in this study. The results are considered to be beneficial for the identification of indications and contraindications in hypertensive patients. Severe bile duct proliferation, portal inflammation, interface hepatitis, focal necrosis and hepatocyte degeneration were demonstrated in the clonidine and amlodipine groups, which had higher oxidant parameters, aspartate aminotransferase, alanine amino transferase and lactate dehydrogenase activity and a higher amount of 8-OH Gua. In the group receiving rilmenidine, all the histopathological findings were the same as those in the clonidine and amlodipine groups, except for bile duct proliferation and interface hepatitis. On histopathological examination of the cell anatomy, it was shown that methyldopa and ramipril caused mild liver damage. While clonidine and amlodipine gave rise to severe liver damage, rilmenidine caused moderate damage, and methyldopa and ramipril led to mild loss of liver function.
format Articulo
Articulo
author Malkoc, Ismail
Cetin, Nihal
Altuner, Durdu
Hacimuftuoglu, Ahmet
Gursan, Nesrin
Bakan, Ebubekir
Akcay, Fatih
Suleyman, Halis
author_facet Malkoc, Ismail
Cetin, Nihal
Altuner, Durdu
Hacimuftuoglu, Ahmet
Gursan, Nesrin
Bakan, Ebubekir
Akcay, Fatih
Suleyman, Halis
author_sort Malkoc, Ismail
title Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
title_short Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
title_full Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
title_fullStr Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
title_full_unstemmed Comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
title_sort comparative review of biochemistry and cell anatomy of the hepatic tissue in rats administered some anti hypertensive drug for a long time
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20178
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_7.pdf
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