Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus

The resistance to antimicrobials and biocides observed in mycobacteria which do not cause tuberculosis (MNT) determines the necessity to develop drugs. The present study evaluated the activity of naphthoquinones and heterocyclic derivatives obtained from lapachol against Mycobacterium kansasii, M. m...

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Autores principales: Cantos, Jéssica B., Coelho, Tatiane S., Carneiro, Paula F., Moura, Kelly C.G. de, Pinto, Maria do C.F.R., Júnior, Eufrânio N. da Silva, Silva, Pedro E.A. da
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Antimycobacterial activity
MNT
Quinones
REMA
Susceptibility
Compuestos Heterocíclicos
Mycobacterium marinum
Mycobacterium kansasii
Quinonas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20170
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20170
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Antimycobacterial activity
MNT
Quinones
REMA
Susceptibility
Compuestos Heterocíclicos
Mycobacterium marinum
Mycobacterium kansasii
Quinonas
spellingShingle Farmacia
Antimycobacterial activity
MNT
Quinones
REMA
Susceptibility
Compuestos Heterocíclicos
Mycobacterium marinum
Mycobacterium kansasii
Quinonas
Cantos, Jéssica B.
Coelho, Tatiane S.
Carneiro, Paula F.
Moura, Kelly C.G. de
Pinto, Maria do C.F.R.
Júnior, Eufrânio N. da Silva
Silva, Pedro E.A. da
Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus
topic_facet Farmacia
Antimycobacterial activity
MNT
Quinones
REMA
Susceptibility
Compuestos Heterocíclicos
Mycobacterium marinum
Mycobacterium kansasii
Quinonas
description The resistance to antimicrobials and biocides observed in mycobacteria which do not cause tuberculosis (MNT) determines the necessity to develop drugs. The present study evaluated the activity of naphthoquinones and heterocyclic derivatives obtained from lapachol against Mycobacterium kansasii, M. marinum, and M. abscessus, through the REMA method. It was observed that lapachol was inactive against the three mycobateria species, while β-lapachone and nor-β-lapachone showed activity only against M. marinum. The most active substances for M. kansasii were the derivates 2, 3, 7, and 11, in which compound 2 (CMI = 0.96 μM) was the most active. For M. marinum, 2, 11, and 14 were the most active, while against M. abcessus the compound 3 was the only active. The results showed a wide and diversified resistance spectrum among the species studied, which could be related to the molecular structure and position of the substituting groups, indicating the potentiality of these molecules as antimicrobial prototypes.
format Articulo
Articulo
author Cantos, Jéssica B.
Coelho, Tatiane S.
Carneiro, Paula F.
Moura, Kelly C.G. de
Pinto, Maria do C.F.R.
Júnior, Eufrânio N. da Silva
Silva, Pedro E.A. da
author_facet Cantos, Jéssica B.
Coelho, Tatiane S.
Carneiro, Paula F.
Moura, Kelly C.G. de
Pinto, Maria do C.F.R.
Júnior, Eufrânio N. da Silva
Silva, Pedro E.A. da
author_sort Cantos, Jéssica B.
title Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus
title_short Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus
title_full Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus
title_fullStr Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus
title_full_unstemmed Antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, M. kansasii and M. abscessus
title_sort antimicrobial evaluation of quinones and heterocyclic compounds against mycobacterium marinum, m. kansasii and m. abscessus
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20170
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_2.pdf
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