A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions

A simple and fast HPLC method has been validated for the determination of clotrimazole in nanocapsule suspensions prepared from an acrylic polymer, Eudragit RS100®. Chromatographic runs were performed on a RP C18 column with a mobile phase comprising methanol and water (90:10, v/v) at a flow rate of...

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Autores principales: Santos, Sara S., Ferreira, Luana M., Schaffazick, Scheila Rezende, Cruz, Leticia
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Clotrimazol
Farmacología
clotrimazole
HPLC
validation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18276
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_2_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18276
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Clotrimazol
Farmacología
clotrimazole
HPLC
validation
spellingShingle Farmacia
Clotrimazol
Farmacología
clotrimazole
HPLC
validation
Santos, Sara S.
Ferreira, Luana M.
Schaffazick, Scheila Rezende
Cruz, Leticia
A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
topic_facet Farmacia
Clotrimazol
Farmacología
clotrimazole
HPLC
validation
description A simple and fast HPLC method has been validated for the determination of clotrimazole in nanocapsule suspensions prepared from an acrylic polymer, Eudragit RS100®. Chromatographic runs were performed on a RP C18 column with a mobile phase comprising methanol and water (90:10, v/v) at a flow rate of 1.0 mL/min with UV detection at 229 nm. The method was shown to be specific, linear (r = 0.9987), precise and accurate in a concentration range of 2.0-10.0 μg/mL. The proposed method can be successfully used to quantify clotrimazole content in acrylic nanocapsule formulations, as well as to estimate drug encapsulation efficiency.
format Articulo
Comunicacion
author Santos, Sara S.
Ferreira, Luana M.
Schaffazick, Scheila Rezende
Cruz, Leticia
author_facet Santos, Sara S.
Ferreira, Luana M.
Schaffazick, Scheila Rezende
Cruz, Leticia
author_sort Santos, Sara S.
title A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
title_short A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
title_full A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
title_fullStr A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
title_full_unstemmed A simple RP-HPLC method for the determination of clotrimazole from acrylic nanocapsule suspensions
title_sort simple rp-hplc method for the determination of clotrimazole from acrylic nanocapsule suspensions
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18276
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_2_1.pdf
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