A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation

A variety of approaches have been studied in the past to overcome the problems encountered with the delivery of antifungal, for effective treating of oral and vaginal candidiasis. In this study, a novel mucoadhesive tablets with pH-independent drug release characteristic was prepared by chitosan and...

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Detalles Bibliográficos
Autores principales:	Pendekal, Mohamed S., Tegginamat, Pramod K.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia candidiasis; carbopol 71G; chitosan; Interpolymer complex; miconazole nitrate Agentes Antifúngicos Candidiasis Bucal Candidiasis Vulvovaginal
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/18273 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_17.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-18273
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia candidiasis; carbopol 71G; chitosan; Interpolymer complex; miconazole nitrate Agentes Antifúngicos Candidiasis Bucal Candidiasis Vulvovaginal
spellingShingle	Farmacia candidiasis; carbopol 71G; chitosan; Interpolymer complex; miconazole nitrate Agentes Antifúngicos Candidiasis Bucal Candidiasis Vulvovaginal Pendekal, Mohamed S. Tegginamat, Pramod K. A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
topic_facet	Farmacia candidiasis; carbopol 71G; chitosan; Interpolymer complex; miconazole nitrate Agentes Antifúngicos Candidiasis Bucal Candidiasis Vulvovaginal
description	A variety of approaches have been studied in the past to overcome the problems encountered with the delivery of antifungal, for effective treating of oral and vaginal candidiasis. In this study, a novel mucoadhesive tablets with pH-independent drug release characteristic was prepared by chitosan and carbopol® 71G interpolymer complex (IPC) claims for multipurpose use. Precipitation method is employed for preparation of IPC followed by characterization with Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimeter (DSC). Bucco-Vaginal Miconazole nitrate (MN) compacts were prepared by direct compression using IPC. The formulations were tested for physicomechanical properties, in vitro drug release (buccal and vaginal pH), swelling studies and mucoadhesion strength. The dissolution of MN from all the prepared tablets into the phosphate buffer (pH 6.8) and simulated vaginal fluid pH 4.2 (SVF) were controlled and followed non-fickian Release mechanism. Formulations containing IPC showed pH independent controlled Miconazole nitrate release without an initial burst release effect in both buccal and vaginal pH. Furthermore, F14 formulations showed satisfactory bioadhesive property and controlled release MN than all other formulations. However, the suitable combination of polymer with IPC exhibited the controlled release MN and satisfactory bioadhesive property with surface erosion along with swelling approached Zero-order release.
format	Articulo Articulo
author	Pendekal, Mohamed S. Tegginamat, Pramod K.
author_facet	Pendekal, Mohamed S. Tegginamat, Pramod K.
author_sort	Pendekal, Mohamed S.
title	A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
title_short	A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
title_full	A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
title_fullStr	A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
title_full_unstemmed	A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
title_sort	novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/18273 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_17.pdf
work_keys_str_mv	AT pendekalmohameds anovelbuccovaginalcontrolledreleasedrugdeliverysystemofmiconazolenitrateforcandidiasisdesignandevaluation AT tegginamatpramodk anovelbuccovaginalcontrolledreleasedrugdeliverysystemofmiconazolenitrateforcandidiasisdesignandevaluation AT pendekalmohameds novelbuccovaginalcontrolledreleasedrugdeliverysystemofmiconazolenitrateforcandidiasisdesignandevaluation AT tegginamatpramodk novelbuccovaginalcontrolledreleasedrugdeliverysystemofmiconazolenitrateforcandidiasisdesignandevaluation
bdutipo_str	Repositorios
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A novel bucco-vaginal controlled release drug delivery system of miconazole nitrate for candidiasis-design and evaluation

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