Biotransformation of Oleanolic Acid by Penicillium melinii

Oleanolic acid (1) is a bioactive compound widely distributed in nature. Microbial transformation is an effective way to alter the structures of compounds. The result of biotransformation of oleanolic acid was carried out in this paper. Four transform products (2-5) from 1 by Penicillium melinii wer...

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Detalles Bibliográficos
Autores principales:	Liu, Dailin, Ai, Ting, Yan, Huijun, Liu, Ying, Liu, Hao, Chen, Hong
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Farmacología antibacterial activity; biotransformation; oleanolic acid; penicillium melinii; triterpenoid Penicilinas Ácido Oleanólico
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/18261 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_13.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-18261
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacología antibacterial activity; biotransformation; oleanolic acid; penicillium melinii; triterpenoid Penicilinas Ácido Oleanólico
spellingShingle	Farmacia Farmacología antibacterial activity; biotransformation; oleanolic acid; penicillium melinii; triterpenoid Penicilinas Ácido Oleanólico Liu, Dailin Ai, Ting Yan, Huijun Liu, Ying Liu, Hao Chen, Hong Biotransformation of Oleanolic Acid by Penicillium melinii
topic_facet	Farmacia Farmacología antibacterial activity; biotransformation; oleanolic acid; penicillium melinii; triterpenoid Penicilinas Ácido Oleanólico
description	Oleanolic acid (1) is a bioactive compound widely distributed in nature. Microbial transformation is an effective way to alter the structures of compounds. The result of biotransformation of oleanolic acid was carried out in this paper. Four transform products (2-5) from 1 by Penicillium melinii were isolated. Their structures were established by spectral data interpretation as 21β-hydroxyoleanolic acid (2), 21α-hydroxyoleanolic acid (3), canthic acid (4), and 7α, 21β-dihydroxyl oleanolic acid (5). Compound 3 had stronger antibacterial activities against MRSA and Staphylococcus aureus than the substrate. It was reported for the first time that the hydroxylation products of oleanic acid can be obtained by biotransformation using incubation with Penicillium melinii.
format	Articulo Articulo
author	Liu, Dailin Ai, Ting Yan, Huijun Liu, Ying Liu, Hao Chen, Hong
author_facet	Liu, Dailin Ai, Ting Yan, Huijun Liu, Ying Liu, Hao Chen, Hong
author_sort	Liu, Dailin
title	Biotransformation of Oleanolic Acid by Penicillium melinii
title_short	Biotransformation of Oleanolic Acid by Penicillium melinii
title_full	Biotransformation of Oleanolic Acid by Penicillium melinii
title_fullStr	Biotransformation of Oleanolic Acid by Penicillium melinii
title_full_unstemmed	Biotransformation of Oleanolic Acid by Penicillium melinii
title_sort	biotransformation of oleanolic acid by penicillium melinii
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/18261 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_13.pdf
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bdutipo_str	Repositorios
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Biotransformation of Oleanolic Acid by Penicillium melinii

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