Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration

The metabolism and excretion profile in rats were investigated after a single dose of daphnoretin. Metabolites of daphnoretin in rats were characterized by HPLC-MS n analysis. A HPLC-UV method was developed to determine the concentration of daphnoretin in rat urine, feces and bile. Daphnoretin was b...

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Detalles Bibliográficos
Autores principales:	Sun, Lixin, Sun, Changshan, Guo, Junyang, Yang, Wengen, Jia, Yurong, Tong, Lijin
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia daphnoretin; excretion; metabolites identification; oral administration Metabolismo Farmacología
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/18255 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_8.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-18255
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia daphnoretin; excretion; metabolites identification; oral administration Metabolismo Farmacología
spellingShingle	Farmacia daphnoretin; excretion; metabolites identification; oral administration Metabolismo Farmacología Sun, Lixin Sun, Changshan Guo, Junyang Yang, Wengen Jia, Yurong Tong, Lijin Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration
topic_facet	Farmacia daphnoretin; excretion; metabolites identification; oral administration Metabolismo Farmacología
description	The metabolism and excretion profile in rats were investigated after a single dose of daphnoretin. Metabolites of daphnoretin in rats were characterized by HPLC-MS n analysis. A HPLC-UV method was developed to determine the concentration of daphnoretin in rat urine, feces and bile. Daphnoretin was biotransformed via conjunctive and oxidative pathways to three detected metabolites. The structures of these metabolites were tentatively identified. The cumulative excretion percentage of daphnoretin in urine, feces and bile of rats was 0.13, 52.7, and 0.018 %, respectively. All the metabolites and excretion data are reported for the first time.
format	Articulo Articulo
author	Sun, Lixin Sun, Changshan Guo, Junyang Yang, Wengen Jia, Yurong Tong, Lijin
author_facet	Sun, Lixin Sun, Changshan Guo, Junyang Yang, Wengen Jia, Yurong Tong, Lijin
author_sort	Sun, Lixin
title	Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration
title_short	Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration
title_full	Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration
title_fullStr	Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration
title_full_unstemmed	Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration
title_sort	metabolism and excretion study of daphnoretin in rats after oral administration
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/18255 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_8.pdf
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bdutipo_str	Repositorios
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Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration

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