Densitometric Determination of Risedronate Sodium in Tablets

An HPTLC method for analysis of risedronate sodium in bulk and pharmaceutical formulation has been established and validated. The analyte was separated on aluminium plates precoated with silica gel 60 F254 . The mobile phase was water-acetontrile-ammonia solution 9.3:0.40:0.3 (v/v). Quantification w...

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Autores principales: Sangshetti, Jaiprakash, Sakhare, Esha, Wavhal, Parmeshwar, Wakte, Pravin S., Shinde, Devanand B.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacología
HPTLC; risedronate sodium; Tablets
Industria Farmacéutica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18254
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18254
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
HPTLC; risedronate sodium; Tablets
Industria Farmacéutica
spellingShingle Farmacia
Farmacología
HPTLC; risedronate sodium; Tablets
Industria Farmacéutica
Sangshetti, Jaiprakash
Sakhare, Esha
Wavhal, Parmeshwar
Wakte, Pravin S.
Shinde, Devanand B.
Densitometric Determination of Risedronate Sodium in Tablets
topic_facet Farmacia
Farmacología
HPTLC; risedronate sodium; Tablets
Industria Farmacéutica
description An HPTLC method for analysis of risedronate sodium in bulk and pharmaceutical formulation has been established and validated. The analyte was separated on aluminium plates precoated with silica gel 60 F254 . The mobile phase was water-acetontrile-ammonia solution 9.3:0.40:0.3 (v/v). Quantification was done by densitometric scanning at 262 nm. Response was a linear function of risedronate asdium concentration in the range of 5 to 25 μg/mL. The limit of detection and quantification for risedronate sodium were 0.86 and 3.03 μg/mL respectively. Average recovery of risedronate sodium was 99.31, which shows that the method was free from interference from excipients present in the formulation. The established method enabled accurate, precise, and rapid analysis of risedronate sodium in bulk as well as pharmaceutical formulation.
format Articulo
Articulo
author Sangshetti, Jaiprakash
Sakhare, Esha
Wavhal, Parmeshwar
Wakte, Pravin S.
Shinde, Devanand B.
author_facet Sangshetti, Jaiprakash
Sakhare, Esha
Wavhal, Parmeshwar
Wakte, Pravin S.
Shinde, Devanand B.
author_sort Sangshetti, Jaiprakash
title Densitometric Determination of Risedronate Sodium in Tablets
title_short Densitometric Determination of Risedronate Sodium in Tablets
title_full Densitometric Determination of Risedronate Sodium in Tablets
title_fullStr Densitometric Determination of Risedronate Sodium in Tablets
title_full_unstemmed Densitometric Determination of Risedronate Sodium in Tablets
title_sort densitometric determination of risedronate sodium in tablets
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18254
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_7.pdf
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AT wavhalparmeshwar densitometricdeterminationofrisedronatesodiumintablets
AT waktepravins densitometricdeterminationofrisedronatesodiumintablets
AT shindedevanandb densitometricdeterminationofrisedronatesodiumintablets
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