In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers

The purpose of the present study was to evaluate the effect of pure and blended mixtures, with different compositions of hydroxy propyl methyl cellulose (HPMC) and carnauba wax (CW) on the release of diclofenac potassium from matrix tablets. Fifteen different matrix tablet formulations were prepared...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Tariq, Imran, Mumtaz, Ahmad M., Saeed, Tariq, Shah, Pervaiz A., Raza, Syed A., Jawa, Najam ul Hassan, Ali, Muhammad Yasir, Abbas, Ghulam
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacología
carnuaba wax; diclofenac potassium; DSC; FTIR; HPMC; sustained release
Industria Farmacéutica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18252
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18252
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
carnuaba wax; diclofenac potassium; DSC; FTIR; HPMC; sustained release
Industria Farmacéutica
spellingShingle Farmacia
Farmacología
carnuaba wax; diclofenac potassium; DSC; FTIR; HPMC; sustained release
Industria Farmacéutica
Tariq, Imran
Mumtaz, Ahmad M.
Saeed, Tariq
Shah, Pervaiz A.
Raza, Syed A.
Jawa, Najam ul Hassan
Ali, Muhammad Yasir
Abbas, Ghulam
In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers
topic_facet Farmacia
Farmacología
carnuaba wax; diclofenac potassium; DSC; FTIR; HPMC; sustained release
Industria Farmacéutica
description The purpose of the present study was to evaluate the effect of pure and blended mixtures, with different compositions of hydroxy propyl methyl cellulose (HPMC) and carnauba wax (CW) on the release of diclofenac potassium from matrix tablets. Fifteen different matrix tablet formulations were prepared by direct compression process by using Carver Hydraulic laboratory press having 13 mm flat dies set at constant pressure. The paddle dissolution apparatus II (Curio DL 2020) was used to assess the dissolution of drug in phosphate buffer, pH 7.4 for 8 h. The release data was fitted to different release models. Zoom stereo micrography was done to evaluated the release mechanism of drug from polymers. The interaction of polymer mixture and different ratios of drug in polymer mixture was determined by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The type and content of polymer in the matrix system influenced the release characteristics. Higher polymeric content in the matrix decreased the drug release rate because of increased tortuosity and decreased porosity. Retardation of drug release from pure carnauba was higher as compared to that with pure HPMC matrices. The polymers blends controlled drug release pattern effectively. The drug released showed better linearity with Higuchi release kinetics. The Korsmeyer equation revealed n value ranged from 0.388-0.627 or non - Fickian transport mechanism of drug release was predominant. The FTIR and DSC suggested that there were no chemical interaction between drug and polymers.
format Articulo
Articulo
author Tariq, Imran
Mumtaz, Ahmad M.
Saeed, Tariq
Shah, Pervaiz A.
Raza, Syed A.
Jawa, Najam ul Hassan
Ali, Muhammad Yasir
Abbas, Ghulam
author_facet Tariq, Imran
Mumtaz, Ahmad M.
Saeed, Tariq
Shah, Pervaiz A.
Raza, Syed A.
Jawa, Najam ul Hassan
Ali, Muhammad Yasir
Abbas, Ghulam
author_sort Tariq, Imran
title In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers
title_short In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers
title_full In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers
title_fullStr In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers
title_full_unstemmed In Vitro Release Studies of Diclofenac Potassium Tablet from Pure and Blended Mixture of Hydrophilic and Hydrophobic Polymers
title_sort in vitro release studies of diclofenac potassium tablet from pure and blended mixture of hydrophilic and hydrophobic polymers
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18252
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_5.pdf
work_keys_str_mv AT tariqimran invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT mumtazahmadm invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT saeedtariq invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT shahpervaiza invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT razasyeda invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT jawanajamulhassan invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT alimuhammadyasir invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
AT abbasghulam invitroreleasestudiesofdiclofenacpotassiumtabletfrompureandblendedmixtureofhydrophilicandhydrophobicpolymers
bdutipo_str Repositorios
_version_ 1764820463982215168

Ejemplares similares