Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride

Six extended-release formulations of tizanidine hydrochloride were prepared by direct compression technique using hydroxypropylmethylcellulose (HPMC) and ethylcellulose (EC). The drug release from these tablets was evaluated by analyzing the samples at 227 nm. Both model dependent and independent ma...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Naeem, Muhammad, Akhter, Khalid P., Ahmad, Ajaz, Aamir, Muhammad N., Aslam, Zartasha
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacología
ethylcellulose; extended-release tablets; factorial design; hydroxypropyl methylcellulose; kinetic models; mathematical modeling; tizanidine hydrochloride
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18246
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18246
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
ethylcellulose; extended-release tablets; factorial design; hydroxypropyl methylcellulose; kinetic models; mathematical modeling; tizanidine hydrochloride
spellingShingle Farmacia
Farmacología
ethylcellulose; extended-release tablets; factorial design; hydroxypropyl methylcellulose; kinetic models; mathematical modeling; tizanidine hydrochloride
Naeem, Muhammad
Akhter, Khalid P.
Ahmad, Ajaz
Aamir, Muhammad N.
Aslam, Zartasha
Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride
topic_facet Farmacia
Farmacología
ethylcellulose; extended-release tablets; factorial design; hydroxypropyl methylcellulose; kinetic models; mathematical modeling; tizanidine hydrochloride
description Six extended-release formulations of tizanidine hydrochloride were prepared by direct compression technique using hydroxypropylmethylcellulose (HPMC) and ethylcellulose (EC). The drug release from these tablets was evaluated by analyzing the samples at 227 nm. Both model dependent and independent mathematical approaches were applied to investigate the extended release pattern and mechanism of tizanidine hydrochloride. About 87.8, 74.4, 85.1, 74.8, 70.8, and 56.2 % drug was released from F1 to F6 , respectively, in 12 h. Drug release kinetics indicated that drug release was best explained by Higuchi equation. The values of ‘n’ from Korsmeyer-Peppas model (0.45 to 0.89) supported anomalous or nonFickian diffusion in first five formulations, whereas last formulation (F6 ) with ‘n’ greater than 0.89 presented case-II relaxation or super case transport-II. In model independent approach, the values of first five formulations lies between 50 and 100, because of insignificant differences in their drug release whereas F6 behaved differently. A retarding effect was observed with both of polymers depending upon their quantity. In F3 and F5 less retarding effect was observed than F2 and F5 because HPMC is hydrophilic and EC is hydrophobic polymer. When EC quantity increased, a decrease in release profile of tizanidine hydrochloride was observed.
format Articulo
Articulo
author Naeem, Muhammad
Akhter, Khalid P.
Ahmad, Ajaz
Aamir, Muhammad N.
Aslam, Zartasha
author_facet Naeem, Muhammad
Akhter, Khalid P.
Ahmad, Ajaz
Aamir, Muhammad N.
Aslam, Zartasha
author_sort Naeem, Muhammad
title Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride
title_short Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride
title_full Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride
title_fullStr Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride
title_full_unstemmed Mathematical Modeling of Drug Release of Novel Extended-Release Formulations of Tizanidine Hydrochloride
title_sort mathematical modeling of drug release of novel extended-release formulations of tizanidine hydrochloride
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18246
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_4.pdf
work_keys_str_mv AT naeemmuhammad mathematicalmodelingofdrugreleaseofnovelextendedreleaseformulationsoftizanidinehydrochloride
AT akhterkhalidp mathematicalmodelingofdrugreleaseofnovelextendedreleaseformulationsoftizanidinehydrochloride
AT ahmadajaz mathematicalmodelingofdrugreleaseofnovelextendedreleaseformulationsoftizanidinehydrochloride
AT aamirmuhammadn mathematicalmodelingofdrugreleaseofnovelextendedreleaseformulationsoftizanidinehydrochloride
AT aslamzartasha mathematicalmodelingofdrugreleaseofnovelextendedreleaseformulationsoftizanidinehydrochloride
bdutipo_str Repositorios
_version_ 1764820463974875139

Ejemplares similares