Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid

The aim of this study was to elaborate the effect of hydrophilic binders on the release profiles of matrix tablets containing mefenamic acid. Mefenamic acid tablets were prepared using wet granulation method. The investigated hydrophilic binders included starch, pectin, tragacanth and honey. It was f...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sial, Atif R., Shah, Syed, Rasool, Fatima, Ranjha, Nazar M., Murtaza, Ghulam
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
dissolution; honey; hydrophilic binders; mefenamic acid; pectin; starch; tragacanth
Ácido Mefenámico
Farmacología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18244
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18244
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
dissolution; honey; hydrophilic binders; mefenamic acid; pectin; starch; tragacanth
Ácido Mefenámico
Farmacología
spellingShingle Farmacia
dissolution; honey; hydrophilic binders; mefenamic acid; pectin; starch; tragacanth
Ácido Mefenámico
Farmacología
Sial, Atif R.
Shah, Syed
Rasool, Fatima
Ranjha, Nazar M.
Murtaza, Ghulam
Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid
topic_facet Farmacia
dissolution; honey; hydrophilic binders; mefenamic acid; pectin; starch; tragacanth
Ácido Mefenámico
Farmacología
description The aim of this study was to elaborate the effect of hydrophilic binders on the release profiles of matrix tablets containing mefenamic acid. Mefenamic acid tablets were prepared using wet granulation method. The investigated hydrophilic binders included starch, pectin, tragacanth and honey. It was found that there was a decrease in the percentage of drug release with the increase in the binder (except tragacanth) concentration, i.e. sustained release behavior was obtained. Zero order model was best fit to all dissolution profiles (indicating controlled release behavior) except that of honey based formulations which followed Higuchi kinetics. It can be concluded from all above stated results that pectin might be considered as a good binder for the tablet formulation of mefenamic acid as compared to lactose as a standard one. Hence the present study justifies the use of pectin as substitute of starch as a binder.
format Articulo
Articulo
author Sial, Atif R.
Shah, Syed
Rasool, Fatima
Ranjha, Nazar M.
Murtaza, Ghulam
author_facet Sial, Atif R.
Shah, Syed
Rasool, Fatima
Ranjha, Nazar M.
Murtaza, Ghulam
author_sort Sial, Atif R.
title Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid
title_short Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid
title_full Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid
title_fullStr Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid
title_full_unstemmed Effect of Different Hydrophillic Binders on the Dissolution Profiles of Mefenamic Acid
title_sort effect of different hydrophillic binders on the dissolution profiles of mefenamic acid
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18244
http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_2.pdf
work_keys_str_mv AT sialatifr effectofdifferenthydrophillicbindersonthedissolutionprofilesofmefenamicacid
AT shahsyed effectofdifferenthydrophillicbindersonthedissolutionprofilesofmefenamicacid
AT rasoolfatima effectofdifferenthydrophillicbindersonthedissolutionprofilesofmefenamicacid
AT ranjhanazarm effectofdifferenthydrophillicbindersonthedissolutionprofilesofmefenamicacid
AT murtazaghulam effectofdifferenthydrophillicbindersonthedissolutionprofilesofmefenamicacid
bdutipo_str Repositorios
_version_ 1764820463971729410

Ejemplares similares