Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate

7-Enthyl-4’-phenylsulfonyldaidzein (EPD 3), a potential prodrug for daidzein, was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient LogP, and hydrolysis kinetics than it...

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Detalles Bibliográficos
Autores principales: Peng, You, Li, Xue-Qin, Hu, Xiao-Ming
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
daidzein sulfonate; crystal structure; prodrug; hydrolysis; partition coefficient
Farmacología
Prodrogas
Preparaciones Farmacéuticas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18145
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18145
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
daidzein sulfonate; crystal structure; prodrug; hydrolysis; partition coefficient
Farmacología
Prodrogas
Preparaciones Farmacéuticas
spellingShingle Farmacia
daidzein sulfonate; crystal structure; prodrug; hydrolysis; partition coefficient
Farmacología
Prodrogas
Preparaciones Farmacéuticas
Peng, You
Li, Xue-Qin
Hu, Xiao-Ming
Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
topic_facet Farmacia
daidzein sulfonate; crystal structure; prodrug; hydrolysis; partition coefficient
Farmacología
Prodrogas
Preparaciones Farmacéuticas
description 7-Enthyl-4’-phenylsulfonyldaidzein (EPD 3), a potential prodrug for daidzein, was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient LogP, and hydrolysis kinetics than its original form. The LogP value (3.07) and the half-life of the hydrolysis value (24.06 h) show that its oral bioavailability is possibly improved evidently compared with that of daidzein. These results indicate that EPD can be considered a potential prodrug for daidzein.
format Articulo
Comunicacion
author Peng, You
Li, Xue-Qin
Hu, Xiao-Ming
author_facet Peng, You
Li, Xue-Qin
Hu, Xiao-Ming
author_sort Peng, You
title Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
title_short Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
title_full Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
title_fullStr Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
title_full_unstemmed Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
title_sort synthesis, crystal structure and prodrug studies of daidzein sulfonate
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18145
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_2_5.pdf
work_keys_str_mv AT pengyou synthesiscrystalstructureandprodrugstudiesofdaidzeinsulfonate
AT lixueqin synthesiscrystalstructureandprodrugstudiesofdaidzeinsulfonate
AT huxiaoming synthesiscrystalstructureandprodrugstudiesofdaidzeinsulfonate
bdutipo_str Repositorios
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