Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
The solid-state characterization, dimorphic nature, solubility and solvent-mediated transformation of the anhydrous form and the monohydrate form of L-phenylalanine have been firstly conducted in detail. The results have shown that, the two forms are enantiotropically related, and the transformatio...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/18127 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_18.pdf |
| Aporte de: |
| Sumario: | The solid-state characterization, dimorphic nature, solubility and solvent-mediated transformation of the anhydrous form and the monohydrate form of L-phenylalanine have been firstly conducted
in detail. The results have shown that, the two forms are enantiotropically related, and the transformation
rate can be prohibited by increasing temperature and reducing water content in the solvent mixtures.
These results will contribute to a better understanding about the pseudopolymorphic systems for pharmaceutical industry. |
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