Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine

The solid-state characterization, dimorphic nature, solubility and solvent-mediated transformation of the anhydrous form and the monohydrate form of L-phenylalanine have been firstly conducted in detail. The results have shown that, the two forms are enantiotropically related, and the transformatio...

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Detalles Bibliográficos
Autores principales: Lu, Jie, Liu, Zhen, Wang, Jing
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacología
active pharmaceutical ingredients; characterization; phenylalanine; pseudopolymorphism; transformation
Aminoácidos
Fenilalanina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18127
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_18.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18127
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
active pharmaceutical ingredients; characterization; phenylalanine; pseudopolymorphism; transformation
Aminoácidos
Fenilalanina
spellingShingle Farmacia
Farmacología
active pharmaceutical ingredients; characterization; phenylalanine; pseudopolymorphism; transformation
Aminoácidos
Fenilalanina
Lu, Jie
Liu, Zhen
Wang, Jing
Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
topic_facet Farmacia
Farmacología
active pharmaceutical ingredients; characterization; phenylalanine; pseudopolymorphism; transformation
Aminoácidos
Fenilalanina
description The solid-state characterization, dimorphic nature, solubility and solvent-mediated transformation of the anhydrous form and the monohydrate form of L-phenylalanine have been firstly conducted in detail. The results have shown that, the two forms are enantiotropically related, and the transformation rate can be prohibited by increasing temperature and reducing water content in the solvent mixtures. These results will contribute to a better understanding about the pseudopolymorphic systems for pharmaceutical industry.
format Articulo
Articulo
author Lu, Jie
Liu, Zhen
Wang, Jing
author_facet Lu, Jie
Liu, Zhen
Wang, Jing
author_sort Lu, Jie
title Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
title_short Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
title_full Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
title_fullStr Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
title_full_unstemmed Pseudopolymorphism of Active Pharmaceutical Ingredients (APIs): A Case Study of L-Phenylalanine
title_sort pseudopolymorphism of active pharmaceutical ingredients (apis): a case study of l-phenylalanine
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18127
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_18.pdf
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AT liuzhen pseudopolymorphismofactivepharmaceuticalingredientsapisacasestudyoflphenylalanine
AT wangjing pseudopolymorphismofactivepharmaceuticalingredientsapisacasestudyoflphenylalanine
bdutipo_str Repositorios
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