Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits

The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) a...

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Detalles Bibliográficos
Autores principales: Rule, Roberto, Petinelli, A., Cordiviola, Carlos Ángel, Prozzi, Guillermo Rafael, Farina, Osvaldo Hugo, Villagra, Sergio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Fenómenos Bioquímicos
cefepime; pharmacokinetics; rabbits; safety
Farmacocinética
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18126
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18126
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Fenómenos Bioquímicos
cefepime; pharmacokinetics; rabbits; safety
Farmacocinética
spellingShingle Farmacia
Fenómenos Bioquímicos
cefepime; pharmacokinetics; rabbits; safety
Farmacocinética
Rule, Roberto
Petinelli, A.
Cordiviola, Carlos Ángel
Prozzi, Guillermo Rafael
Farina, Osvaldo Hugo
Villagra, Sergio
Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
topic_facet Farmacia
Fenómenos Bioquímicos
cefepime; pharmacokinetics; rabbits; safety
Farmacocinética
description The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC = 387.4 ± 132.2 μg/mL.h; Vss = 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification.
format Articulo
Articulo
author Rule, Roberto
Petinelli, A.
Cordiviola, Carlos Ángel
Prozzi, Guillermo Rafael
Farina, Osvaldo Hugo
Villagra, Sergio
author_facet Rule, Roberto
Petinelli, A.
Cordiviola, Carlos Ángel
Prozzi, Guillermo Rafael
Farina, Osvaldo Hugo
Villagra, Sergio
author_sort Rule, Roberto
title Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
title_short Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
title_full Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
title_fullStr Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
title_full_unstemmed Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
title_sort pharmacokinetics and evaluation of the safety of cefepime administered to rabbits
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18126
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf
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