Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers
Alpha-blockers (alfuzosin, tamsulosin, doxazosin, prazosin and terazosin) relax the smooth muscles in the prostate and are indicated for the symptomatic treatment of benign prostatic hyperplasia due to evidence of their positive and rapid effect on lower urinary tract symptoms. Our objective was t...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/18125 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_16.pdf |
| Aporte de: |
| id |
I19-R120-10915-18125 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia alfuzosin; doxazosin; estimation of alpha-one blockers; method validation; prazosin; terazosinM; tamsulosin Farmacología Agentes Adrenérgicos Procesos Fisiológicos del Tracto Urinario |
| spellingShingle |
Farmacia alfuzosin; doxazosin; estimation of alpha-one blockers; method validation; prazosin; terazosinM; tamsulosin Farmacología Agentes Adrenérgicos Procesos Fisiológicos del Tracto Urinario Shrivatava, Alankar Gupta, Vipin B. Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers |
| topic_facet |
Farmacia alfuzosin; doxazosin; estimation of alpha-one blockers; method validation; prazosin; terazosinM; tamsulosin Farmacología Agentes Adrenérgicos Procesos Fisiológicos del Tracto Urinario |
| description |
Alpha-blockers (alfuzosin, tamsulosin, doxazosin, prazosin and terazosin) relax the smooth
muscles in the prostate and are indicated for the symptomatic treatment of benign prostatic hyperplasia
due to evidence of their positive and rapid effect on lower urinary tract symptoms. Our objective was to
develop and validate simultaneous estimation of these drugs. Same class of drugs may have almost same
functional groups and therefore research focused on development of RPLC and HPTLC method for simultaneous quantitative determination. The separation was achieved in HPLC method on a C18 column, a
UV detector at 230 nm and a elution was performed under a gradient mobile phase composed of (A) ACNdiethylamine (0.05 mL), (B) methanol, (C) 10 mM ammonium acetate and (D) Water. For HPTLC method
separation was achieved by using mobile phase chloroform and methanol in the ratio 9.5:0.5. Both of the
validated methods can be utilized for the assay of these α1
adrenoreceptors in pharmaceutical industries. |
| format |
Articulo Articulo |
| author |
Shrivatava, Alankar Gupta, Vipin B. |
| author_facet |
Shrivatava, Alankar Gupta, Vipin B. |
| author_sort |
Shrivatava, Alankar |
| title |
Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers |
| title_short |
Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers |
| title_full |
Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers |
| title_fullStr |
Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers |
| title_full_unstemmed |
Validated HPLC and HPTLC Methods for Simultaneous Determination of Some α1 -Adrenoreceptor Blockers |
| title_sort |
validated hplc and hptlc methods for simultaneous determination of some α1 -adrenoreceptor blockers |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/18125 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_16.pdf |
| work_keys_str_mv |
AT shrivatavaalankar validatedhplcandhptlcmethodsforsimultaneousdeterminationofsomea1adrenoreceptorblockers AT guptavipinb validatedhplcandhptlcmethodsforsimultaneousdeterminationofsomea1adrenoreceptorblockers |
| bdutipo_str |
Repositorios |
| _version_ |
1764820463845900291 |