Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies

Cefuroxime axetil (CA) immediate release (IR) tablets were developed and optimized by direct compression method. Ten formulations were designed and optimized using central composite design with two main variables, microcrystalline cellulose PH 102 and croscarmellose. Pharmaceutical evaluation of the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Muhammad, Iyad N., Yousuf, Rabia I., Hanif, Muhammad, Shoaib, Muhammad Harris, Jabeen, Sabahat, Ali, Tariq
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacología
cefuroxime axetil; centre composite design; formulation development; formulation optimization; similarity factor f2; stability under stress conditions
Cefuroxima
Compuestos Orgánicos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18124
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-18124
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
cefuroxime axetil; centre composite design; formulation development; formulation optimization; similarity factor f2; stability under stress conditions
Cefuroxima
Compuestos Orgánicos
spellingShingle Farmacia
Farmacología
cefuroxime axetil; centre composite design; formulation development; formulation optimization; similarity factor f2; stability under stress conditions
Cefuroxima
Compuestos Orgánicos
Muhammad, Iyad N.
Yousuf, Rabia I.
Hanif, Muhammad
Shoaib, Muhammad Harris
Jabeen, Sabahat
Ali, Tariq
Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
topic_facet Farmacia
Farmacología
cefuroxime axetil; centre composite design; formulation development; formulation optimization; similarity factor f2; stability under stress conditions
Cefuroxima
Compuestos Orgánicos
description Cefuroxime axetil (CA) immediate release (IR) tablets were developed and optimized by direct compression method. Ten formulations were designed and optimized using central composite design with two main variables, microcrystalline cellulose PH 102 and croscarmellose. Pharmaceutical evaluation of the formulations was conducted emphasizing on dissolution profile of the drug by USP dissolution test using apparatus II in 0.07 N HCl and in medium of pH 1.2, 4.5 and 6.8 to determine the dissolution pattern of the low soluble drug. Test formulations were compared against reference brand using f2 similarity factor. Test formulations were assayed by a validated HPLC method, with acetonitrile and 10 mM ammonium acetate solution (pH = 5.2) in a ratio of 15:85 as mobile phase. Stability studies under stress were conducted on selected formulations according to ICH guidelines. It was conclusive that stable CA formulations could be developed by direct compression method.
format Articulo
Articulo
author Muhammad, Iyad N.
Yousuf, Rabia I.
Hanif, Muhammad
Shoaib, Muhammad Harris
Jabeen, Sabahat
Ali, Tariq
author_facet Muhammad, Iyad N.
Yousuf, Rabia I.
Hanif, Muhammad
Shoaib, Muhammad Harris
Jabeen, Sabahat
Ali, Tariq
author_sort Muhammad, Iyad N.
title Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
title_short Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
title_full Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
title_fullStr Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
title_full_unstemmed Formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
title_sort formulation development and optimization of cefuroxime axetil tablets by direct compression method and its stability studies
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/18124
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_15.pdf
work_keys_str_mv AT muhammadiyadn formulationdevelopmentandoptimizationofcefuroximeaxetiltabletsbydirectcompressionmethodanditsstabilitystudies
AT yousufrabiai formulationdevelopmentandoptimizationofcefuroximeaxetiltabletsbydirectcompressionmethodanditsstabilitystudies
AT hanifmuhammad formulationdevelopmentandoptimizationofcefuroximeaxetiltabletsbydirectcompressionmethodanditsstabilitystudies
AT shoaibmuhammadharris formulationdevelopmentandoptimizationofcefuroximeaxetiltabletsbydirectcompressionmethodanditsstabilitystudies
AT jabeensabahat formulationdevelopmentandoptimizationofcefuroximeaxetiltabletsbydirectcompressionmethodanditsstabilitystudies
AT alitariq formulationdevelopmentandoptimizationofcefuroximeaxetiltabletsbydirectcompressionmethodanditsstabilitystudies
bdutipo_str Repositorios
_version_ 1764820463844851713

Ejemplares similares